The significance of wheezing in chronic airflow obstruction

J. J. Marini, D. J. Pierson, L. D. Hudson, S. Lakshminarayan

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


Eighty-three patients with chronic airflow obstruction were examined prospectively to determine the relationships among wheezing intensity, severity of obstruction, and response to inhaled isoproterenol. For each patient, expiratory wheezing scores were assigned during deep unforced breathing and during forced vital capacity efforts at spirometry. Unforced wheezing scores were independently correlated with severity of obstruction (r=0.42) and bronchodilator response (r=0.46), but these correlatons did not permit consistent prediction of either variable for clinical purposes. The highest wheezing scores, however, were uniformly associated with moderate or severe obstruction. Twenty-nine of 48 patients with wheezing but only 3 of 35 patients without wheezing demonstrated 15% or greater improvement in one-second forced expiratory volume after bronchodilator inhalation (p<0.001). Wheezing during forced exhalation was not correlated with either degree of obstruction or bronchodilator response.

Original languageEnglish (US)
Pages (from-to)1069-1072
Number of pages4
JournalAmerican Review of Respiratory Disease
Issue number5
StatePublished - Dec 1 1979


Dive into the research topics of 'The significance of wheezing in chronic airflow obstruction'. Together they form a unique fingerprint.

Cite this