The self-obsession of T cells: How TCR signaling thresholds affect fate 'decisions' and effector function

Research output: Contribution to journalArticlepeer-review

200 Scopus citations

Abstract

Self-reactivity was once seen as a potential characteristic of T cells that was eliminated by clonal selection to protect the host from autoimmune pathology. It is now understood that the T cell repertoire is in fact broadly self-reactive, even self-centered. The strength with which a T cell reacts to self ligands and the environmental context in which this reaction occurs influence almost every aspect of T cell biology, from development to differentiation to effector function. Here we highlight recent advances and discoveries that relate to T cell self-reactivity, with a particular emphasis on T cell antigen receptor (TCR) signaling thresholds.

Original languageEnglish (US)
Pages (from-to)815-823
Number of pages9
JournalNature immunology
Volume15
Issue number9
DOIs
StatePublished - Sep 2014

Bibliographical note

Funding Information:
Supported by the US National Institutes of Health (PO1 AI35296, RO1 AI088209 and R37 AI39560 to K.A.H., and R01 AI75168 and R37 AI38903 to S.C.J.).

Fingerprint

Dive into the research topics of 'The self-obsession of T cells: How TCR signaling thresholds affect fate 'decisions' and effector function'. Together they form a unique fingerprint.

Cite this