The search for orally active medications through combinatorial chemistry

Robert A. Fecik, Kristine E. Frank, Elmer J. Gentry, Sanjay R. Menon, Lester A. Mitscher, Hanumaiah Telikepalli

Research output: Contribution to journalReview articlepeer-review

87 Scopus citations

Abstract

The literature of combinatorial chemistry is reviewed with particular attention paid to considerations of absorption, distribution, metabolism and excretion in the design and evaluation of libraries containing drug-like molecules. Published libraries are evaluated in particular for the likelihood that the products would possess oral bioavailability.

Original languageEnglish (US)
Pages (from-to)149-185
Number of pages37
JournalMedicinal Research Reviews
Volume18
Issue number3
DOIs
StatePublished - May 1 1998

Keywords

  • Absorption
  • Combinatorial chemistry
  • Distribution
  • Excretion
  • Heterocyclic centroids
  • Metabolism
  • Oral activity

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