The literature of combinatorial chemistry is reviewed with particular attention paid to considerations of absorption, distribution, metabolism and excretion in the design and evaluation of libraries containing drug-like molecules. Published libraries are evaluated in particular for the likelihood that the products would possess oral bioavailability.
|Original language||English (US)|
|Number of pages||37|
|Journal||Medicinal Research Reviews|
|State||Published - May 1 1998|
- Combinatorial chemistry
- Heterocyclic centroids
- Oral activity