The search for orally active medications through combinatorial chemistry

Robert A. Fecik, Kristine E. Frank, Elmer J. Gentry, Sanjay R. Menon, Lester A. Mitscher, Hanumaiah Telikepalli

Research output: Contribution to journalReview articlepeer-review

91 Scopus citations


The literature of combinatorial chemistry is reviewed with particular attention paid to considerations of absorption, distribution, metabolism and excretion in the design and evaluation of libraries containing drug-like molecules. Published libraries are evaluated in particular for the likelihood that the products would possess oral bioavailability.

Original languageEnglish (US)
Pages (from-to)149-185
Number of pages37
JournalMedicinal Research Reviews
Issue number3
StatePublished - May 1998


  • Absorption
  • Combinatorial chemistry
  • Distribution
  • Excretion
  • Heterocyclic centroids
  • Metabolism
  • Oral activity


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