The search for orally active medications through combinatorial chemistry

Robert A. Fecik; Kristine E. Frank; Elmer J. Gentry; Sanjay R. Menon; Lester A. Mitscher; Hanumaiah Telikepalli

doi:10.1002/(SICI)1098-1128(199805)18:3<149::AID-MED2>3.0.CO;2-X

The search for orally active medications through combinatorial chemistry

Robert A. Fecik, Kristine E. Frank, Elmer J. Gentry, Sanjay R. Menon, Lester A. Mitscher, Hanumaiah Telikepalli

Medicinal Chemistry

Research output: Contribution to journal › Review article › peer-review

91 Scopus citations

Abstract

The literature of combinatorial chemistry is reviewed with particular attention paid to considerations of absorption, distribution, metabolism and excretion in the design and evaluation of libraries containing drug-like molecules. Published libraries are evaluated in particular for the likelihood that the products would possess oral bioavailability.

Original language	English (US)
Pages (from-to)	149-185
Number of pages	37
Journal	Medicinal Research Reviews
Volume	18
Issue number	3
DOIs	https://doi.org/10.1002/(SICI)1098-1128(199805)18:3<149::AID-MED2>3.0.CO;2-X
State	Published - May 1998

Keywords

Absorption
Combinatorial chemistry
Distribution
Excretion
Heterocyclic centroids
Metabolism
Oral activity

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10.1002/(SICI)1098-1128(199805)18:3<149::AID-MED2>3.0.CO;2-X

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abstract = "The literature of combinatorial chemistry is reviewed with particular attention paid to considerations of absorption, distribution, metabolism and excretion in the design and evaluation of libraries containing drug-like molecules. Published libraries are evaluated in particular for the likelihood that the products would possess oral bioavailability.",

keywords = "Absorption, Combinatorial chemistry, Distribution, Excretion, Heterocyclic centroids, Metabolism, Oral activity",

author = "Fecik, {Robert A.} and Frank, {Kristine E.} and Gentry, {Elmer J.} and Menon, {Sanjay R.} and Mitscher, {Lester A.} and Hanumaiah Telikepalli",

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AU - Fecik, Robert A.

AU - Frank, Kristine E.

AU - Gentry, Elmer J.

AU - Menon, Sanjay R.

AU - Mitscher, Lester A.

AU - Telikepalli, Hanumaiah

PY - 1998/5

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N2 - The literature of combinatorial chemistry is reviewed with particular attention paid to considerations of absorption, distribution, metabolism and excretion in the design and evaluation of libraries containing drug-like molecules. Published libraries are evaluated in particular for the likelihood that the products would possess oral bioavailability.

AB - The literature of combinatorial chemistry is reviewed with particular attention paid to considerations of absorption, distribution, metabolism and excretion in the design and evaluation of libraries containing drug-like molecules. Published libraries are evaluated in particular for the likelihood that the products would possess oral bioavailability.

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KW - Combinatorial chemistry

KW - Distribution

KW - Excretion

KW - Heterocyclic centroids

KW - Metabolism

KW - Oral activity

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JO - Medicinal Research Reviews

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The search for orally active medications through combinatorial chemistry

Abstract

Keywords

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