The salivary protein BPIFA2 differentially regulates sodium preference and blood pressure in male and female mice

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Abstract

BPIFA2 (PSP, SPLUNC2, C20orf70) is a major salivary protein of uncertain physiological function. BPIFA2 is downregulated in salivary glands of spontaneously hypertensive rats, pointing to a role in blood pressure regulation. This study used a novel Bpifa2 knockout mouse model to test the role of BPIFA2 in sodium preference and blood pressure. Blood pressure did not differ between wild-type male and female mice but was significantly lower in male knockout mice compared to male wild-type mice. In contrast, blood pressure was increased in female knockout mice compared to female wild-type mice. Female wild-type mice showed a significant preference for 0.9% saline compared to male mice. This difference was reduced in the knockout mice. BPIFA2 is an LPS-binding protein but it remains to be determined if the reported effects are mediated by the LPS-binding activity of BPIFA2.

Original languageEnglish (US)
Article numbere18
JournalExperimental Results
Volume1
DOIs
StatePublished - Jul 3 2020

Bibliographical note

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Keywords

  • hypertension
  • Saliva
  • sodium intake
  • SPLUNC2

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