The safety assessment of fragrance materials

David R. Bickers, Peter Calow, Helmut A. Greim, Jon M. Hanifin, Adrianne E. Rogers, Jean Hilaire Saurat, I. Glenn Sipes, Robert L. Smith, Hachiro Tagami

    Research output: Contribution to journalReview article

    75 Citations (Scopus)

    Abstract

    Safety evaluation of the large number of diverse chemicals used as fragrance ingredients follows a systematic prioritization of data generation and analysis, consideration of exposure and critical analysis of the quality of the available information. In prior publications the research priorities used by the Research Institute for Fragrance Materials (RIFM), and the methods of exposure estimation used by industry have been summarized. This paper provides details of the approach used by the RIFM Expert Panel (REXPAN), to examine the dermal effects, systemic toxicity and environmental consequences of the use of and exposure to fragrance materials, which allow a reliable determination of safe use under intended conditions. The key to the usefulness of this analysis is the grouping of more than 2600 discrete ingredients into classes, based on chemical structures. Research sponsored by RIFM, data supplied by member companies, and relevant published reports from many sources are all considered during hazard characterization. A discussion is provided of REXPAN's decision tree approach to assessing the dermal, systemic and environmental endpoints and the types and quality of data included. This overall process results in well-documented conclusions which are provided to the International Fragrance Association (IFRA) as the basis for consideration of a new or existing Fragrance Material Standard and to industry for appropriate product risk management actions.

    Original languageEnglish (US)
    Pages (from-to)218-273
    Number of pages56
    JournalRegulatory Toxicology and Pharmacology
    Volume37
    Issue number2
    DOIs
    StatePublished - Jan 1 2003

    Fingerprint

    Fragrances
    Safety
    Industry
    Decision Trees
    Skin
    Risk Management
    Research
    Publications
    Decision trees
    Risk management
    Toxicity
    Hazards

    Cite this

    Bickers, D. R., Calow, P., Greim, H. A., Hanifin, J. M., Rogers, A. E., Saurat, J. H., ... Tagami, H. (2003). The safety assessment of fragrance materials. Regulatory Toxicology and Pharmacology, 37(2), 218-273. https://doi.org/10.1016/S0273-2300(03)00003-5

    The safety assessment of fragrance materials. / Bickers, David R.; Calow, Peter; Greim, Helmut A.; Hanifin, Jon M.; Rogers, Adrianne E.; Saurat, Jean Hilaire; Sipes, I. Glenn; Smith, Robert L.; Tagami, Hachiro.

    In: Regulatory Toxicology and Pharmacology, Vol. 37, No. 2, 01.01.2003, p. 218-273.

    Research output: Contribution to journalReview article

    Bickers, DR, Calow, P, Greim, HA, Hanifin, JM, Rogers, AE, Saurat, JH, Sipes, IG, Smith, RL & Tagami, H 2003, 'The safety assessment of fragrance materials', Regulatory Toxicology and Pharmacology, vol. 37, no. 2, pp. 218-273. https://doi.org/10.1016/S0273-2300(03)00003-5
    Bickers DR, Calow P, Greim HA, Hanifin JM, Rogers AE, Saurat JH et al. The safety assessment of fragrance materials. Regulatory Toxicology and Pharmacology. 2003 Jan 1;37(2):218-273. https://doi.org/10.1016/S0273-2300(03)00003-5
    Bickers, David R. ; Calow, Peter ; Greim, Helmut A. ; Hanifin, Jon M. ; Rogers, Adrianne E. ; Saurat, Jean Hilaire ; Sipes, I. Glenn ; Smith, Robert L. ; Tagami, Hachiro. / The safety assessment of fragrance materials. In: Regulatory Toxicology and Pharmacology. 2003 ; Vol. 37, No. 2. pp. 218-273.
    @article{8aa9f8fe6fe2455ea1db02cd7ecd4561,
    title = "The safety assessment of fragrance materials",
    abstract = "Safety evaluation of the large number of diverse chemicals used as fragrance ingredients follows a systematic prioritization of data generation and analysis, consideration of exposure and critical analysis of the quality of the available information. In prior publications the research priorities used by the Research Institute for Fragrance Materials (RIFM), and the methods of exposure estimation used by industry have been summarized. This paper provides details of the approach used by the RIFM Expert Panel (REXPAN), to examine the dermal effects, systemic toxicity and environmental consequences of the use of and exposure to fragrance materials, which allow a reliable determination of safe use under intended conditions. The key to the usefulness of this analysis is the grouping of more than 2600 discrete ingredients into classes, based on chemical structures. Research sponsored by RIFM, data supplied by member companies, and relevant published reports from many sources are all considered during hazard characterization. A discussion is provided of REXPAN's decision tree approach to assessing the dermal, systemic and environmental endpoints and the types and quality of data included. This overall process results in well-documented conclusions which are provided to the International Fragrance Association (IFRA) as the basis for consideration of a new or existing Fragrance Material Standard and to industry for appropriate product risk management actions.",
    author = "Bickers, {David R.} and Peter Calow and Greim, {Helmut A.} and Hanifin, {Jon M.} and Rogers, {Adrianne E.} and Saurat, {Jean Hilaire} and Sipes, {I. Glenn} and Smith, {Robert L.} and Hachiro Tagami",
    year = "2003",
    month = "1",
    day = "1",
    doi = "10.1016/S0273-2300(03)00003-5",
    language = "English (US)",
    volume = "37",
    pages = "218--273",
    journal = "Regulatory Toxicology and Pharmacology",
    issn = "0273-2300",
    publisher = "Academic Press Inc.",
    number = "2",

    }

    TY - JOUR

    T1 - The safety assessment of fragrance materials

    AU - Bickers, David R.

    AU - Calow, Peter

    AU - Greim, Helmut A.

    AU - Hanifin, Jon M.

    AU - Rogers, Adrianne E.

    AU - Saurat, Jean Hilaire

    AU - Sipes, I. Glenn

    AU - Smith, Robert L.

    AU - Tagami, Hachiro

    PY - 2003/1/1

    Y1 - 2003/1/1

    N2 - Safety evaluation of the large number of diverse chemicals used as fragrance ingredients follows a systematic prioritization of data generation and analysis, consideration of exposure and critical analysis of the quality of the available information. In prior publications the research priorities used by the Research Institute for Fragrance Materials (RIFM), and the methods of exposure estimation used by industry have been summarized. This paper provides details of the approach used by the RIFM Expert Panel (REXPAN), to examine the dermal effects, systemic toxicity and environmental consequences of the use of and exposure to fragrance materials, which allow a reliable determination of safe use under intended conditions. The key to the usefulness of this analysis is the grouping of more than 2600 discrete ingredients into classes, based on chemical structures. Research sponsored by RIFM, data supplied by member companies, and relevant published reports from many sources are all considered during hazard characterization. A discussion is provided of REXPAN's decision tree approach to assessing the dermal, systemic and environmental endpoints and the types and quality of data included. This overall process results in well-documented conclusions which are provided to the International Fragrance Association (IFRA) as the basis for consideration of a new or existing Fragrance Material Standard and to industry for appropriate product risk management actions.

    AB - Safety evaluation of the large number of diverse chemicals used as fragrance ingredients follows a systematic prioritization of data generation and analysis, consideration of exposure and critical analysis of the quality of the available information. In prior publications the research priorities used by the Research Institute for Fragrance Materials (RIFM), and the methods of exposure estimation used by industry have been summarized. This paper provides details of the approach used by the RIFM Expert Panel (REXPAN), to examine the dermal effects, systemic toxicity and environmental consequences of the use of and exposure to fragrance materials, which allow a reliable determination of safe use under intended conditions. The key to the usefulness of this analysis is the grouping of more than 2600 discrete ingredients into classes, based on chemical structures. Research sponsored by RIFM, data supplied by member companies, and relevant published reports from many sources are all considered during hazard characterization. A discussion is provided of REXPAN's decision tree approach to assessing the dermal, systemic and environmental endpoints and the types and quality of data included. This overall process results in well-documented conclusions which are provided to the International Fragrance Association (IFRA) as the basis for consideration of a new or existing Fragrance Material Standard and to industry for appropriate product risk management actions.

    UR - http://www.scopus.com/inward/record.url?scp=0037395707&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=0037395707&partnerID=8YFLogxK

    U2 - 10.1016/S0273-2300(03)00003-5

    DO - 10.1016/S0273-2300(03)00003-5

    M3 - Review article

    C2 - 12726755

    AN - SCOPUS:0037395707

    VL - 37

    SP - 218

    EP - 273

    JO - Regulatory Toxicology and Pharmacology

    JF - Regulatory Toxicology and Pharmacology

    SN - 0273-2300

    IS - 2

    ER -