The roles of tumor-derived exosomes in cancer pathogenesis

Chenjie Yang, Paul D. Robbins

Research output: Contribution to journalReview article

192 Scopus citations

Abstract

Exosomes are endosome-derived, 30-100nm small membrane vesicles released by most cell types including tumor cells. They are enriched in a selective repertoire of proteins and nucleic acids from parental cells and are thought to be actively involved in conferring intercellular signals. Tumor-derived exosomes have been viewed as a source of tumor antigens that can be used to induce antitumor immune responses. However, tumor-derived exosomes also have been found to possess immunosuppressive properties and are able to facilitate tumor growth, metastasis, and the development of drug resistance. These different effects of tumor-derived exosomes contribute to the pathogenesis of cancer. This review will discuss the roles of tumor-derived exosomes in cancer pathogenesis, therapy, and diagnostics.

Original languageEnglish (US)
Article number842849
JournalClinical and Developmental Immunology
Volume2011
DOIs
StatePublished - Dec 1 2011
Externally publishedYes

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