The roles of picornavirus untranslated regions in infection and innate immunity

Anna Kloc, Devendra K. Rai, Elizabeth Rieder

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations

Abstract

Viral genomes have evolved to maximize their potential of overcoming host defense mechanisms and to induce a variety of disease syndromes. Structurally, a genome of a virus consists of coding and noncoding regions, and both have been shown to contribute to initiation and progression of disease. Accumulated work in picornaviruses has stressed out the importance of the noncoding RNAs, or untranslated 5'- and 3'-regions (UTRs), in both replication and translation of viral genomes. Unsurprisingly, defects in these processes have been reported to cause viral attenuation and affect viral pathogenicity. However, substantial evidence suggests that these untranslated RNAs may influence the outcome of the host innate immune response. This review discusses the involvement of 5'- and 3'-terminus UTRs in induction and regulation of host immunity and its consequences for viral life cycle and virulence.

Original languageEnglish (US)
Article number485
JournalFrontiers in Microbiology
Volume9
Issue numberMAR
DOIs
StatePublished - Mar 20 2018

Keywords

  • 5'- and 3'-UTRs
  • Foot-and-mouth disease virus (FMDV)
  • Modulation of innate immunity
  • Picornaviruses
  • RNA functional elements
  • RNA viruses

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