The roles of CD8 in cytotoxic T lymphocyte function

Anne M. O'Rourke, Matthew F Mescher

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

The CD8 glycoprotein of cytotoxic T cells is both an adhesion protein and a cosignalling receptor. These functions are regulated by signals from the T-cell antigen receptor complex (TCR-CD3), and CD8 acts to couple TCR occupancy to second messenger pathways. Here Anne O'Rourke and Matthew Mescher examine the roles of CD8 in activating the adhesion and signalling cascade initiated by antigen binding.

Original languageEnglish (US)
Pages (from-to)177-183
Number of pages7
JournalImmunology Today
Volume14
Issue number4
DOIs
StatePublished - Apr 1993

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