The roles of CD8 in cytotoxic T lymphocyte function

Anne M. O'Rourke; Matthew F Mescher

doi:10.1016/0167-5699(93)90283-Q

The roles of CD8 in cytotoxic T lymphocyte function

Anne M. O'Rourke, Matthew F Mescher

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

The CD8 glycoprotein of cytotoxic T cells is both an adhesion protein and a cosignalling receptor. These functions are regulated by signals from the T-cell antigen receptor complex (TCR-CD3), and CD8 acts to couple TCR occupancy to second messenger pathways. Here Anne O'Rourke and Matthew Mescher examine the roles of CD8 in activating the adhesion and signalling cascade initiated by antigen binding.

Original language	English (US)
Pages (from-to)	177-183
Number of pages	7
Journal	Immunology Today
Volume	14
Issue number	4
DOIs	https://doi.org/10.1016/0167-5699(93)90283-Q
State	Published - Apr 1993

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title = "The roles of CD8 in cytotoxic T lymphocyte function",

abstract = "The CD8 glycoprotein of cytotoxic T cells is both an adhesion protein and a cosignalling receptor. These functions are regulated by signals from the T-cell antigen receptor complex (TCR-CD3), and CD8 acts to couple TCR occupancy to second messenger pathways. Here Anne O'Rourke and Matthew Mescher examine the roles of CD8 in activating the adhesion and signalling cascade initiated by antigen binding.",

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AB - The CD8 glycoprotein of cytotoxic T cells is both an adhesion protein and a cosignalling receptor. These functions are regulated by signals from the T-cell antigen receptor complex (TCR-CD3), and CD8 acts to couple TCR occupancy to second messenger pathways. Here Anne O'Rourke and Matthew Mescher examine the roles of CD8 in activating the adhesion and signalling cascade initiated by antigen binding.

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The roles of CD8 in cytotoxic T lymphocyte function

Abstract

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