The roles of CD8 in cytotoxic T lymphocyte function

Anne M. O'Rourke, Matthew F. Mescher

Research output: Contribution to journalArticlepeer-review


The CD8 glycoprotein of cytotoxic T cells is both an adhesion protein and a cosignalling receptor. These functions are regulated by signals from the T-cell antigen receptor complex (TCR-CD3), and CD8 acts to couple TCR occupancy to second messenger pathways. Here Anne O'Rourke and Matthew Mescher examine the roles of CD8 in activating the adhesion and signalling cascade initiated by antigen binding.

Original languageEnglish (US)
Pages (from-to)177-183
Number of pages7
JournalTrends in Immunology
Issue number4
StatePublished - Apr 1993


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