The roles of CD8 in cytotoxic T lymphocyte function

Anne M. O'Rourke, Matthew F. Mescher

Research output: Contribution to journalReview articlepeer-review

63 Scopus citations


The CD8 glycoprotein of cytotoxic T cells is both an adhesion protein and a cosignalling receptor. These functions are regulated by signals from the T-cell antigen receptor complex (TCR-CD3), and CD8 acts to couple TCR occupancy to second messenger pathways. Here Anne O'Rourke and Matthew Mescher examine the roles of CD8 in activating the adhesion and signalling cascade initiated by antigen binding.

Original languageEnglish (US)
Pages (from-to)183-188
Number of pages6
JournalImmunology Today
Issue number4
StatePublished - Jan 1 1993


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