The role of unconventional myosins in Dictyostelium endocytosis

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Abstract

Dictyostelium discoideum is a simple eukaryote amenable to detailed molecular studies of the endocytic processes phagocytosis and macropinocytosis. Both the actin cytoskeleton and associated myosin motors are well-described and a range of mutants are now available that enable characterization of the role of the cytoskeleton in a range of cellular functions. Molecular genetic studies have uncovered roles for two different classes of Dictyostelium unconventional myosins in endocytosis. The class I myosins contribute to both macropinocytosis and phagocytosis by playing a general role in controlling actin-dependent manipulations of the actin-rich cortex. A class VII myosin has been shown to be important for phagocytosis. This brief review summarizes what is known about the role of these different myosins in both fluid and particle uptake in this system.

Original languageEnglish (US)
Pages (from-to)191-196
Number of pages6
JournalJournal of Eukaryotic Microbiology
Volume47
Issue number3
DOIs
StatePublished - Jan 1 2000

Keywords

  • Macropinocytosis
  • Myosin I
  • Myosin VIIa
  • Phagocytosis

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