The role of type-2 Turkey astrovirus in poult enteritis syndrome

S. K. Mor, M. Abin, G. Costa, A. Durrani, N. Jindal, S. M. Goyal, D. P. Patnayak

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

An experimental study was conducted to determine the comparative pathogenicity of type-2 Turkey astrovirus (TAstV-2) obtained from Turkey flocks afflicted with poult enteritis syndrome (PES) and from Turkey flocks displaying no apparent signs of infection. In total, ninety 7-d-old poults, which tested negative for the presence of astrovirus, rotavirus, coronavirus, and reovirus by reverse transcriptase (RT) PCR, were divided evenly into 3 groups: A, B, and C. Birds in group A were inoculated orally with Turkey astrovirus-positive intestinal contents from birds affected with PES. Group B received Turkey astrovirus-containing intestinal contents from apparently healthy flocks. Group C served as a negative control and was given PBS. Clinical signs of diarrhea, depression, and dullness were observed in group A. Birds in group B also showed clinical signs similar to those in group A, although the signs were milder in nature. Birds in group C did not show any clinical signs. At 16 d postinoculation, the BW of birds in group A was significantly lower than that of birds in groups B or C. In addition, the bursa size was reduced in group A, but not in groups B or C. Birds in groups A and B, but not in group C, were found to shed Turkey astrovirus in their feces, as detected by RTPCR. These results provide a preliminary indication that TAstV-2 from PES birds may be more pathogenic than TAstV-2 from apparently healthy poults. Further studies are needed to determine if pathogenic and nonpathogenic strains of TAstV-2 exist in the environment. These results also reinforce our previous observations that astrovirus is involved in PES, causing significant retardation in growth and weight gain.

Original languageEnglish (US)
Pages (from-to)2747-2752
Number of pages6
JournalPoultry science
Volume90
Issue number12
DOIs
StatePublished - Dec 2011

Bibliographical note

Funding Information:
This work was funded in part with a research grant from Rapid Agricultural Response Fund, University of Minnesota (St. Paul).

Keywords

  • Comparative pathogenicity
  • Growth depression
  • Pathogenic astrovirus
  • Poult enteritis syndrome
  • Virus variation

Fingerprint Dive into the research topics of 'The role of type-2 Turkey astrovirus in poult enteritis syndrome'. Together they form a unique fingerprint.

Cite this