TY - JOUR
T1 - The Role of Total Pancreatectomy and Islet Autotransplantation for Chronic Pancreatitis
AU - Blondet, Juan J.
AU - Carlson, Annelisa M.
AU - Kobayashi, Takashi
AU - Jie, Tun
AU - Bellin, Melena
AU - Hering, Bernhard J.
AU - Freeman, Martin L.
AU - Beilman, Greg J.
AU - Sutherland, David E R
PY - 2007/12
Y1 - 2007/12
N2 - Total pancreatectomy and islet autotransplantation are done for chronic pancreatitis with intractable pain when other treatment measures have failed, allowing insulin secretory capacity to be preserved, minimizing or preventing diabetes, while at the same time removing the root cause of the pain. Since the first case in 1977, several series have been published. Pain relief is obtained in most patients, and insulin independence preserved long term in about a third, with another third having sufficient beta cell function so that the surgical diabetes is mild. Islet autotransplantation has been done with partial or total pancreatectomy for benign and premalignant conditions. Islet autotransplantation should be used more widely to preserve beta cell mass in major pancreatic resections.
AB - Total pancreatectomy and islet autotransplantation are done for chronic pancreatitis with intractable pain when other treatment measures have failed, allowing insulin secretory capacity to be preserved, minimizing or preventing diabetes, while at the same time removing the root cause of the pain. Since the first case in 1977, several series have been published. Pain relief is obtained in most patients, and insulin independence preserved long term in about a third, with another third having sufficient beta cell function so that the surgical diabetes is mild. Islet autotransplantation has been done with partial or total pancreatectomy for benign and premalignant conditions. Islet autotransplantation should be used more widely to preserve beta cell mass in major pancreatic resections.
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U2 - 10.1016/j.suc.2007.08.014
DO - 10.1016/j.suc.2007.08.014
M3 - Review article
C2 - 18053843
AN - SCOPUS:36348950274
SN - 0039-6109
VL - 87
SP - 1477
EP - 1501
JO - Surgical Clinics of North America
JF - Surgical Clinics of North America
IS - 6
ER -