The role of TNF receptor and TNF superfamily molecules in organ transplantation

Andrew B. Adams, Christian P. Larsen, Thomas C. Pearson, Kenneth A. Newell

Research output: Contribution to journalShort surveypeer-review

45 Scopus citations


The rapid increase in the number of molecules demonstrated to regulate immune responses has provided new opportunities for manipulation of the recipient immune response to transplanted organs. Molecules belonging to the TNF receptors and TNF superfamily are increasingly recognized as playing a major role in the regulation of immune responses to tumor, viral, and autoantigens. The mechanisms by which these molecules regulate immune responses are diverse. TNF receptor-related molecules have been shown to control the development of secondary lymphoid organs, affect the activation and survival of T cells and antigen presenting cells, and alter cytokine and chemokine production. An increasing amount of data suggest that some TNFR superfamily members are particularly important for the function of CD8+ T cells. Based on our current understanding of these molecules it seems highly likely that strategies that target selected TNFR/ TNF superfamily molecules will be useful for controlling or preventing the rejection of transplanted organs and tissues.

Original languageEnglish (US)
Pages (from-to)12-18
Number of pages7
JournalAmerican Journal of Transplantation
Issue number1
StatePublished - Jan 2002
Externally publishedYes


  • Allograft rejection
  • CD8 T cell
  • Costimulation
  • TNF receptor


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