The role of tissue repair and leukocytes in the pathogenesis of emphysema

J. R. Hoidal; Dennis E Niewoehner

doi:10.1378/chest.83.5.58s

The role of tissue repair and leukocytes in the pathogenesis of emphysema

J. R. Hoidal, Dennis E Niewoehner

Medicine - Veteran's Administration Medical Center

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The results of the study suggest that the same lung injury might result in either emphysema or fibrosis, connective tissue synthesis during the healing phase being the critical determinant. Furthermore, in the model described, neutrophils do not appear to be essential mediators of the emphysema which developed. We suggest that common lung toxins, such as cigarette smoke, may have important effects upon the healing phase after injury.

Original language	English (US)
Pages (from-to)	58S-59S
Journal	CHEST
Volume	83
Issue number	5 Suppl.
DOIs	https://doi.org/10.1378/chest.83.5.58s
State	Published - Jan 1 1983

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title = "The role of tissue repair and leukocytes in the pathogenesis of emphysema",

abstract = "The results of the study suggest that the same lung injury might result in either emphysema or fibrosis, connective tissue synthesis during the healing phase being the critical determinant. Furthermore, in the model described, neutrophils do not appear to be essential mediators of the emphysema which developed. We suggest that common lung toxins, such as cigarette smoke, may have important effects upon the healing phase after injury.",

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AB - The results of the study suggest that the same lung injury might result in either emphysema or fibrosis, connective tissue synthesis during the healing phase being the critical determinant. Furthermore, in the model described, neutrophils do not appear to be essential mediators of the emphysema which developed. We suggest that common lung toxins, such as cigarette smoke, may have important effects upon the healing phase after injury.

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