The Role of the MCM2-7 Helicase Subunit MCM2 in Epigenetic Inheritance

Jing Jia; Chuanhe Yu

doi:10.3390/biology13080572

The Role of the MCM2-7 Helicase Subunit MCM2 in Epigenetic Inheritance

Jing Jia, Chuanhe Yu

The Hormel Institute

Research output: Contribution to journal › Review article › peer-review

Abstract

Recycling histone proteins from parental chromatin, a process known as parental histone transfer, is an important component in chromosome replication and is essential for epigenetic inheritance. We review recent advances in our understanding of the recycling mechanism of parental histone H3-H4 tetramers (parH3:H4tet), emphasizing the pivotal role of the DNA replisome. In particular, we highlight the function of the MCM2-7 helicase subunit Mcm2 as a histone H3-H4 tetramer chaperone. Disruption of this histone chaperone’s functions affects mouse embryonic stem cell differentiation and can lead to embryonic lethality in mice, underscoring the crucial role of the replisome in maintaining epigenomic stability.

Original language	English (US)
Article number	572
Journal	Biology
Volume	13
Issue number	8
DOIs	https://doi.org/10.3390/biology13080572
State	Published - Aug 2024

Bibliographical note

Publisher Copyright:
© 2024 by the authors.

Keywords

cell differentiation
Dpb3
Dpb4
eSPAN
FACS
histone chaperone
MCM2
Pol1
Pol32

PubMed: MeSH publication types

Journal Article
Review

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10.3390/biology13080572

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title = "The Role of the MCM2-7 Helicase Subunit MCM2 in Epigenetic Inheritance",

abstract = "Recycling histone proteins from parental chromatin, a process known as parental histone transfer, is an important component in chromosome replication and is essential for epigenetic inheritance. We review recent advances in our understanding of the recycling mechanism of parental histone H3-H4 tetramers (parH3:H4tet), emphasizing the pivotal role of the DNA replisome. In particular, we highlight the function of the MCM2-7 helicase subunit Mcm2 as a histone H3-H4 tetramer chaperone. Disruption of this histone chaperone{\textquoteright}s functions affects mouse embryonic stem cell differentiation and can lead to embryonic lethality in mice, underscoring the crucial role of the replisome in maintaining epigenomic stability.",

keywords = "cell differentiation, Dpb3, Dpb4, eSPAN, FACS, histone chaperone, MCM2, Pol1, Pol32",

author = "Jing Jia and Chuanhe Yu",

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language = "English (US)",

volume = "13",

journal = "Biology",

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T1 - The Role of the MCM2-7 Helicase Subunit MCM2 in Epigenetic Inheritance

AU - Jia, Jing

AU - Yu, Chuanhe

PY - 2024/8

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N2 - Recycling histone proteins from parental chromatin, a process known as parental histone transfer, is an important component in chromosome replication and is essential for epigenetic inheritance. We review recent advances in our understanding of the recycling mechanism of parental histone H3-H4 tetramers (parH3:H4tet), emphasizing the pivotal role of the DNA replisome. In particular, we highlight the function of the MCM2-7 helicase subunit Mcm2 as a histone H3-H4 tetramer chaperone. Disruption of this histone chaperone’s functions affects mouse embryonic stem cell differentiation and can lead to embryonic lethality in mice, underscoring the crucial role of the replisome in maintaining epigenomic stability.

AB - Recycling histone proteins from parental chromatin, a process known as parental histone transfer, is an important component in chromosome replication and is essential for epigenetic inheritance. We review recent advances in our understanding of the recycling mechanism of parental histone H3-H4 tetramers (parH3:H4tet), emphasizing the pivotal role of the DNA replisome. In particular, we highlight the function of the MCM2-7 helicase subunit Mcm2 as a histone H3-H4 tetramer chaperone. Disruption of this histone chaperone’s functions affects mouse embryonic stem cell differentiation and can lead to embryonic lethality in mice, underscoring the crucial role of the replisome in maintaining epigenomic stability.

KW - cell differentiation

KW - Dpb3

KW - Dpb4

KW - eSPAN

KW - FACS

KW - histone chaperone

KW - MCM2

KW - Pol1

KW - Pol32

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U2 - 10.3390/biology13080572

DO - 10.3390/biology13080572

M3 - Review article

C2 - 39194510

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SN - 2079-7737

VL - 13

JO - Biology

JF - Biology

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ER -

The Role of the MCM2-7 Helicase Subunit MCM2 in Epigenetic Inheritance

Abstract

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Keywords

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