BACKGROUND: While a majority of cigarette smokers who use electronic cigarettes (e-cigarettes) choose to continue using cigarettes, completely switching to e-cigarettes is necessary to reduce tobacco-related harm. Whether specific subjective responses to e-cigarettes are associated with extent of smoking reduction and complete switching from cigarettes to e-cigarettes is unclear. This study determined whether initial subjective responses to e-cigarettes related to the successful substitution of e-cigarettes for cigarettes and extent of cigarette and e-cigarette use.
METHODS: Adult cigarette smokers (N = 58) uninterested in quitting were asked to completely substitute their cigarettes with an e-cigarette (Vuse Solo) for 8 weeks. At week 1, subjective responses to e-cigarettes were measured using the Product Evaluation Scale and Drug Effects/Liking Survey. A Poisson regression examined whether any of these initial subjective responses were associated with smoke-free days, e-cigarette puffs, and cigarettes smoked between weeks 6 and 8 after adjustment for potential confounders. A logistic regression examined the relationship between subjective measures and exhaled carbon monoxide (CO) verified 7-day abstinence at week 8 after adjustment for potential confounders.
RESULTS: Following Holm's p-value adjustment, e-cigarette liking and desire were associated with increased e-cigarette use (adjusted p < 0.01) and decreased cigarette use (adjusted p < 0.05). Measures of psychological reward and drug liking were associated with 7-day abstinence, however this association was no longer significant following p-value adjustment.
CONCLUSIONS: Initial subjective responses were related to cigarette and e-cigarette use at weeks 6-8, but not smoke-free days or CO-verified 7-day abstinence.
Bibliographical noteFunding Information:
Research reported in this publication was supported by grants U19CA157345 from the National Cancer Institute (DKH/PS), UL1 TR000062 from the National Center for Advancing Translational Science of the National Institutes of Health , and T32 DA007097 from the National Institute of Drug Abuse (MSG; EM). The content is solely the responsibility of the authors and does not necessarily represent the official views of the funding agencies.
© 2020 Elsevier B.V.
- Abuse liability
- Electronic cigarettes
- Tobacco regulatory science
PubMed: MeSH publication types
- Journal Article
- Research Support, N.I.H., Extramural