TY - JOUR
T1 - The Role of Stem Cells in the Treatment of Cerebral Palsy
T2 - a Review
AU - Kiasatdolatabadi, Anahita
AU - Lotfibakhshaiesh, Nasrin
AU - Yazdankhah, Meysam
AU - Ebrahimi-Barough, Somayeh
AU - Jafarabadi, Mina
AU - Ai, Arman
AU - Sadroddiny, Esmaeil
AU - Ai, Jafar
N1 - Publisher Copyright:
© 2016, Springer Science+Business Media New York.
PY - 2017/9/1
Y1 - 2017/9/1
N2 - Cerebral palsy (CP) is a neuromuscular disease due to injury in the infant’s brain. The CP disorder causes many neurologic dysfunctions in the patient. Various treatment methods have been used for the management of CP disorder. However, there has been no absolute cure for this condition. Furthermore, some of the procedures which are currently used for relief of symptoms in CP cause discomfort or side effects in the patient. Recently, stem cell therapy has attracted a huge interest as a new therapeutic method for treatment of CP. Several investigations in animal and human with CP have demonstrated positive potential of stem cell transplantation for the treatment of CP disorder. The ultimate goal of this therapeutic method is to harness the regenerative capacity of the stem cells causing a formation of new tissues to replace the damaged tissue. During the recent years, there have been many investigations on stem cell therapy. However, there are still many unclear issues regarding this method and high effort is needed to create a technology as a perfect treatment. This review will discuss the scientific background of stem cell therapy for cerebral palsy including evidences from current clinical trials.
AB - Cerebral palsy (CP) is a neuromuscular disease due to injury in the infant’s brain. The CP disorder causes many neurologic dysfunctions in the patient. Various treatment methods have been used for the management of CP disorder. However, there has been no absolute cure for this condition. Furthermore, some of the procedures which are currently used for relief of symptoms in CP cause discomfort or side effects in the patient. Recently, stem cell therapy has attracted a huge interest as a new therapeutic method for treatment of CP. Several investigations in animal and human with CP have demonstrated positive potential of stem cell transplantation for the treatment of CP disorder. The ultimate goal of this therapeutic method is to harness the regenerative capacity of the stem cells causing a formation of new tissues to replace the damaged tissue. During the recent years, there have been many investigations on stem cell therapy. However, there are still many unclear issues regarding this method and high effort is needed to create a technology as a perfect treatment. This review will discuss the scientific background of stem cell therapy for cerebral palsy including evidences from current clinical trials.
KW - Cerebral palsy
KW - Clinical trials
KW - Stem cell
KW - Treatment
UR - http://www.scopus.com/inward/record.url?scp=84982133178&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84982133178&partnerID=8YFLogxK
U2 - 10.1007/s12035-016-0030-0
DO - 10.1007/s12035-016-0030-0
M3 - Review article
C2 - 27520277
AN - SCOPUS:84982133178
SN - 0893-7648
VL - 54
SP - 4963
EP - 4972
JO - Molecular neurobiology
JF - Molecular neurobiology
IS - 7
ER -