The role of STAT5 in the development, function, and transformation of B and T lymphocytes

Lynn M. Heltemes-Harris, Mark J.L. Willette, Kieng B. Vang, Michael A. Farrar

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

The transcription factor signal transducer and activator of transcription 5 (STAT5) is activated by a number of cytokine and growth hormone receptors and plays a key role in the development and function of many organ systems. In this review, we focus on recent discoveries about the role of STAT5 in the development and function of B and T lymphocytes. Of particular interest is the growing appreciation for the function of STAT5 as a transcriptional repressor. Finally, we discuss recent discoveries about the role of STAT5 in transformation of B and T lymphocytes.

Original languageEnglish (US)
Pages (from-to)18-31
Number of pages14
JournalAnnals of the New York Academy of Sciences
Volume1217
Issue number1
DOIs
StatePublished - Jan 2011

Keywords

  • Leukemia
  • Lymphocyte development
  • Lymphoma
  • STAT5
  • Transformation

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