The role of STAT5 in lymphocyte development and transformation

Lynn M. Heltemes-Harris, Michael A. Farrar

Research output: Contribution to journalReview articlepeer-review

39 Scopus citations


STAT5 plays a crucial role in B and T lymphocyte development. However, whether STAT5 primarily plays a role as a permissive factor, involved in lymphocyte survival, or an instructive factor, involved in lymphocyte differentiation, has been unclear. In addition, while STAT5 has been suggested to act as a transcriptional repressor, the mechanism by which it represses transcription was undefined. Recent reports have begun to shed new light on these roles for STAT5 in lymphocyte development, transcriptional repression, and leukemic transformation.

Original languageEnglish (US)
Pages (from-to)146-152
Number of pages7
JournalCurrent Opinion in Immunology
Issue number2
StatePublished - Apr 2012

Bibliographical note

Copyright 2012 Elsevier B.V., All rights reserved.


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