TY - JOUR
T1 - The role of STAT5 in lymphocyte development and transformation
AU - Heltemes-Harris, Lynn M.
AU - Farrar, Michael A.
PY - 2012/4
Y1 - 2012/4
N2 - STAT5 plays a crucial role in B and T lymphocyte development. However, whether STAT5 primarily plays a role as a permissive factor, involved in lymphocyte survival, or an instructive factor, involved in lymphocyte differentiation, has been unclear. In addition, while STAT5 has been suggested to act as a transcriptional repressor, the mechanism by which it represses transcription was undefined. Recent reports have begun to shed new light on these roles for STAT5 in lymphocyte development, transcriptional repression, and leukemic transformation.
AB - STAT5 plays a crucial role in B and T lymphocyte development. However, whether STAT5 primarily plays a role as a permissive factor, involved in lymphocyte survival, or an instructive factor, involved in lymphocyte differentiation, has been unclear. In addition, while STAT5 has been suggested to act as a transcriptional repressor, the mechanism by which it represses transcription was undefined. Recent reports have begun to shed new light on these roles for STAT5 in lymphocyte development, transcriptional repression, and leukemic transformation.
UR - http://www.scopus.com/inward/record.url?scp=84859159648&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84859159648&partnerID=8YFLogxK
U2 - 10.1016/j.coi.2012.01.015
DO - 10.1016/j.coi.2012.01.015
M3 - Review article
C2 - 22342169
AN - SCOPUS:84859159648
SN - 0952-7915
VL - 24
SP - 146
EP - 152
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
IS - 2
ER -