The role of selected factors in the development and consequences of alcohol dependence

Rebecca Gilbertson, Robert Prather, Sara J o Nixon

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations


Gender, family history, comorbid psychiatric and substance use disorders, and age all influence a person's risk for alcoholism. In addition, these factors interact with alcoholism to influence neurocognitive functioning following detoxification. This article examines these factors and considers how they interact with each other. This complexity reinforces the need for both animal and human studies and suggests multiple factors that may be sensitive to differential prevention, intervention, and treatment efforts. Thus, it is imperative that hypothesis-driven research designs be directed to identifying the relative potency of these factors and their interactions.

Original languageEnglish (US)
Pages (from-to)389-399
Number of pages11
JournalAlcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism
Issue number4
StatePublished - 2008


  • Age of AODU onset
  • Alcohol and other drug (AOD) dependence
  • Alcoholism
  • AOD effects
  • Brain
  • Comorbidity
  • Environmental factors
  • Family AOD use (AODU) history
  • Family factors
  • Gender differences
  • Genetic factors
  • Multiple drug use
  • Risk factors


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