The role of motor proteins in photoreceptor protein transport and visual function

Rakesh Radhakrishnan; Venkateshwara R. Dronamraju; Matthias M Leung; Andrew Gruesen; Ashish K. Solanki; Stephen Walterhouse; Heidi Roehrich; Rafael da Costa Monsanto; Sebahattin Cureoglu; René Martin; Altaf A. Kondkar; Frederik J. van Kuijk; Sandra R. Montezuma; Hans Joachim Knöelker; Robert B. Hufnagel; Grace S Song; Glenn P. Lobo

doi:10.1080/13816810.2022.2062391

The role of motor proteins in photoreceptor protein transport and visual function

Rakesh Radhakrishnan, Venkateshwara R. Dronamraju, Matthias M Leung, Andrew Gruesen, Ashish K. Solanki, Stephen Walterhouse, Heidi Roehrich, Rafael da Costa Monsanto, Sebahattin Cureoglu, René Martin, Altaf A. Kondkar, Frederik J. van Kuijk, Sandra R. Montezuma, Hans Joachim Knöelker, Robert B. Hufnagel, Grace S Song, Glenn P. Lobo

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

Background: Rods and cones are photoreceptor neurons in the retina that are required for visual sensation in vertebrates, wherein the perception of vision is initiated when these neurons respond to photons in the light stimuli. The photoreceptor cell is structurally studied as outer segments (OS) and inner segments (IS) where proper protein sorting, localization, and compartmentalization are critical for phototransduction, visual function, and survival. In human retinal diseases, improper protein transport to the OS or mislocalization of proteins to the IS and other cellular compartments could lead to impaired visual responses and photoreceptor cell degeneration that ultimately cause loss of visual function. Results: Therefore, studying and identifying mechanisms involved in facilitating and maintaining proper protein transport in photoreceptor cells would help our understanding of pathologies involving retinal cell degeneration in inherited retinal dystrophies, age-related macular degeneration, and Usher Syndrome. Conclusions: Our mini-review will discuss mechanisms of protein transport within photoreceptors and introduce a novel role for an unconventional motor protein, MYO1C, in actin-based motor transport of the visual chromophore Rhodopsin to the OS, in support of phototransduction and visual function.

Original language	English (US)
Pages (from-to)	285-300
Number of pages	16
Journal	Ophthalmic Genetics
Volume	43
Issue number	3
DOIs	https://doi.org/10.1080/13816810.2022.2062391 https://doi.org/10.1080/13816810.2022.2062391
State	Published - May 4 2022

Bibliographical note

Funding Information:
This work was supported by the National Institute of Health–National Eye Institute (NIH/NEI) grants EY025034 and EY030889 to G.P.L. We thank Dr Beata Jastrzebska, Ph.D. (Department of Pharmacology, Case Western Reserve University, OH, USA) for a critical review of this manuscript. We also thank Dr Deepak Nihalani, Ph.D. (NIH/NIDKK) for helpful discussions.

Publisher Copyright:
© 2022 The Author(s). Published with license by Taylor & Francis Group, LLC.

Keywords

Motor protein
Myosin 1C
Rhodopsin
actin
outer segments
photoreceptor
protein localization
retinal degeneration
trafficking
visual function

PubMed: MeSH publication types

Journal Article
Research Support, N.I.H., Extramural

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Radhakrishnan, R., Dronamraju, V. R., Leung, M. M., Gruesen, A., Solanki, A. K., Walterhouse, S., Roehrich, H., da Costa Monsanto, R., Cureoglu, S., Martin, R., Kondkar, A. A., van Kuijk, F. J., Montezuma, S. R., Knöelker, H. J., Hufnagel, R. B., Song, G. S., & Lobo, G. P. (2022). The role of motor proteins in photoreceptor protein transport and visual function. Ophthalmic Genetics, 43(3), 285-300. https://doi.org/10.1080/13816810.2022.2062391, https://doi.org/10.1080/13816810.2022.2062391

Radhakrishnan, R, Dronamraju, VR, Leung, MM, Gruesen, A, Solanki, AK, Walterhouse, S, Roehrich, H, da Costa Monsanto, R, Cureoglu, S, Martin, R, Kondkar, AA, van Kuijk, FJ , Montezuma, SR, Knöelker, HJ, Hufnagel, RB, Song, GS & Lobo, GP 2022, 'The role of motor proteins in photoreceptor protein transport and visual function', Ophthalmic Genetics, vol. 43, no. 3, pp. 285-300. https://doi.org/10.1080/13816810.2022.2062391, https://doi.org/10.1080/13816810.2022.2062391

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title = "The role of motor proteins in photoreceptor protein transport and visual function",

abstract = "Background: Rods and cones are photoreceptor neurons in the retina that are required for visual sensation in vertebrates, wherein the perception of vision is initiated when these neurons respond to photons in the light stimuli. The photoreceptor cell is structurally studied as outer segments (OS) and inner segments (IS) where proper protein sorting, localization, and compartmentalization are critical for phototransduction, visual function, and survival. In human retinal diseases, improper protein transport to the OS or mislocalization of proteins to the IS and other cellular compartments could lead to impaired visual responses and photoreceptor cell degeneration that ultimately cause loss of visual function. Results: Therefore, studying and identifying mechanisms involved in facilitating and maintaining proper protein transport in photoreceptor cells would help our understanding of pathologies involving retinal cell degeneration in inherited retinal dystrophies, age-related macular degeneration, and Usher Syndrome. Conclusions: Our mini-review will discuss mechanisms of protein transport within photoreceptors and introduce a novel role for an unconventional motor protein, MYO1C, in actin-based motor transport of the visual chromophore Rhodopsin to the OS, in support of phototransduction and visual function.",

keywords = "Motor protein, Myosin 1C, Rhodopsin, actin, outer segments, photoreceptor, protein localization, retinal degeneration, trafficking, visual function",

author = "Rakesh Radhakrishnan and Dronamraju, {Venkateshwara R.} and Leung, {Matthias M} and Andrew Gruesen and Solanki, {Ashish K.} and Stephen Walterhouse and Heidi Roehrich and {da Costa Monsanto}, Rafael and Sebahattin Cureoglu and Ren{\'e} Martin and Kondkar, {Altaf A.} and {van Kuijk}, {Frederik J.} and Montezuma, {Sandra R.} and Kn{\"o}elker, {Hans Joachim} and Hufnagel, {Robert B.} and Song, {Grace S} and Lobo, {Glenn P.}",

note = "Funding Information: This work was supported by the National Institute of Health–National Eye Institute (NIH/NEI) grants EY025034 and EY030889 to G.P.L. We thank Dr Beata Jastrzebska, Ph.D. (Department of Pharmacology, Case Western Reserve University, OH, USA) for a critical review of this manuscript. We also thank Dr Deepak Nihalani, Ph.D. (NIH/NIDKK) for helpful discussions. Publisher Copyright: {\textcopyright} 2022 The Author(s). Published with license by Taylor & Francis Group, LLC.",

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doi = "10.1080/13816810.2022.2062391",

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T1 - The role of motor proteins in photoreceptor protein transport and visual function

AU - Radhakrishnan, Rakesh

AU - Dronamraju, Venkateshwara R.

AU - Leung, Matthias M

AU - Gruesen, Andrew

AU - Solanki, Ashish K.

AU - Walterhouse, Stephen

AU - Roehrich, Heidi

AU - da Costa Monsanto, Rafael

AU - Cureoglu, Sebahattin

AU - Martin, René

AU - Kondkar, Altaf A.

AU - van Kuijk, Frederik J.

AU - Montezuma, Sandra R.

AU - Knöelker, Hans Joachim

AU - Hufnagel, Robert B.

AU - Song, Grace S

AU - Lobo, Glenn P.

N1 - Funding Information: This work was supported by the National Institute of Health–National Eye Institute (NIH/NEI) grants EY025034 and EY030889 to G.P.L. We thank Dr Beata Jastrzebska, Ph.D. (Department of Pharmacology, Case Western Reserve University, OH, USA) for a critical review of this manuscript. We also thank Dr Deepak Nihalani, Ph.D. (NIH/NIDKK) for helpful discussions. Publisher Copyright: © 2022 The Author(s). Published with license by Taylor & Francis Group, LLC.

PY - 2022/5/4

Y1 - 2022/5/4

N2 - Background: Rods and cones are photoreceptor neurons in the retina that are required for visual sensation in vertebrates, wherein the perception of vision is initiated when these neurons respond to photons in the light stimuli. The photoreceptor cell is structurally studied as outer segments (OS) and inner segments (IS) where proper protein sorting, localization, and compartmentalization are critical for phototransduction, visual function, and survival. In human retinal diseases, improper protein transport to the OS or mislocalization of proteins to the IS and other cellular compartments could lead to impaired visual responses and photoreceptor cell degeneration that ultimately cause loss of visual function. Results: Therefore, studying and identifying mechanisms involved in facilitating and maintaining proper protein transport in photoreceptor cells would help our understanding of pathologies involving retinal cell degeneration in inherited retinal dystrophies, age-related macular degeneration, and Usher Syndrome. Conclusions: Our mini-review will discuss mechanisms of protein transport within photoreceptors and introduce a novel role for an unconventional motor protein, MYO1C, in actin-based motor transport of the visual chromophore Rhodopsin to the OS, in support of phototransduction and visual function.

AB - Background: Rods and cones are photoreceptor neurons in the retina that are required for visual sensation in vertebrates, wherein the perception of vision is initiated when these neurons respond to photons in the light stimuli. The photoreceptor cell is structurally studied as outer segments (OS) and inner segments (IS) where proper protein sorting, localization, and compartmentalization are critical for phototransduction, visual function, and survival. In human retinal diseases, improper protein transport to the OS or mislocalization of proteins to the IS and other cellular compartments could lead to impaired visual responses and photoreceptor cell degeneration that ultimately cause loss of visual function. Results: Therefore, studying and identifying mechanisms involved in facilitating and maintaining proper protein transport in photoreceptor cells would help our understanding of pathologies involving retinal cell degeneration in inherited retinal dystrophies, age-related macular degeneration, and Usher Syndrome. Conclusions: Our mini-review will discuss mechanisms of protein transport within photoreceptors and introduce a novel role for an unconventional motor protein, MYO1C, in actin-based motor transport of the visual chromophore Rhodopsin to the OS, in support of phototransduction and visual function.

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KW - Myosin 1C

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KW - protein localization

KW - retinal degeneration

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KW - visual function

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The role of motor proteins in photoreceptor protein transport and visual function

Abstract

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Keywords

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