The role of mitochondria in redox signaling of muscle homeostasis

Li Li Ji, Dongwook Yeo, Choung-Hun Kang, Tianou Zhang

Research output: Contribution to journalReview articlepeer-review

27 Scopus citations


In the past, contraction-induced production of reactive oxygen species (ROS) has been implicated in oxidative stress to skeletal muscle. As research advances, clear evidence has revealed a more complete role of ROS under both physiologic and pathologic conditions. Central to the role of ROS is the redox signaling pathways that control exercise-induced major physiologic and cellular responses and adaptations, such as mitochondrial biogenesis, mitophagy, mitochondrial morphologic dynamics, antioxidant defense, and inflammation. The current review focuses on how muscle contraction and immobilization may activate or inhibit redox signalings and their impact on muscle mitochondrial homeostasis and physiologic implications.

Original languageEnglish (US)
Pages (from-to)386-393
Number of pages8
JournalJournal of Sport and Health Science
Issue number5
StatePublished - Sep 2020

Bibliographical note

Publisher Copyright:
© 2020


  • Antioxidant
  • Exercise
  • Peroxisome-proliferator-activated receptor γ coactivator 1-α
  • Reactive oxygen species
  • Redox signaling
  • Skeletal muscle


Dive into the research topics of 'The role of mitochondria in redox signaling of muscle homeostasis'. Together they form a unique fingerprint.

Cite this