The role of lipid droplets in metabolic disease in rodents and humans

Andrew S. Greenberg, Rosalind A. Coleman, Fredric B. Kraemer, James L. McManaman, Martin S. Obin, Vishwajeet Puri, Qing Wu Yan, Hideaki Miyoshi, Douglas G. Mashek

Research output: Contribution to journalReview article

329 Citations (Scopus)

Abstract

Lipid droplets (LDs) are intracellular organelles that store neutral lipids within cells. Over the last two decades there has been a dramatic growth in our understanding of LD biology and, in parallel, our understanding of the role of LDs in health and disease. In its simplest form, the LD regulates the storage and hydrolysis of neutral lipids, including triacylglycerol and/or cholesterol esters. It is becoming increasingly evident that alterations in the regulation of LD physiology and metabolism influence the risk of developing metabolic diseases such as diabetes. In this review we provide an update on the role of LD-associated proteins and LDs in metabolic disease.

Original languageEnglish (US)
Pages (from-to)2102-2110
Number of pages9
JournalJournal of Clinical Investigation
Volume121
Issue number6
DOIs
StatePublished - Jun 1 2011

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Metabolic Diseases
Rodentia
Lipids
Cholesterol Esters
Lipid Metabolism
Organelles
Lipid Droplets
Triglycerides
Hydrolysis
Health
Growth

Cite this

Greenberg, A. S., Coleman, R. A., Kraemer, F. B., McManaman, J. L., Obin, M. S., Puri, V., ... Mashek, D. G. (2011). The role of lipid droplets in metabolic disease in rodents and humans. Journal of Clinical Investigation, 121(6), 2102-2110. https://doi.org/10.1172/JCI46069

The role of lipid droplets in metabolic disease in rodents and humans. / Greenberg, Andrew S.; Coleman, Rosalind A.; Kraemer, Fredric B.; McManaman, James L.; Obin, Martin S.; Puri, Vishwajeet; Yan, Qing Wu; Miyoshi, Hideaki; Mashek, Douglas G.

In: Journal of Clinical Investigation, Vol. 121, No. 6, 01.06.2011, p. 2102-2110.

Research output: Contribution to journalReview article

Greenberg, AS, Coleman, RA, Kraemer, FB, McManaman, JL, Obin, MS, Puri, V, Yan, QW, Miyoshi, H & Mashek, DG 2011, 'The role of lipid droplets in metabolic disease in rodents and humans', Journal of Clinical Investigation, vol. 121, no. 6, pp. 2102-2110. https://doi.org/10.1172/JCI46069
Greenberg AS, Coleman RA, Kraemer FB, McManaman JL, Obin MS, Puri V et al. The role of lipid droplets in metabolic disease in rodents and humans. Journal of Clinical Investigation. 2011 Jun 1;121(6):2102-2110. https://doi.org/10.1172/JCI46069
Greenberg, Andrew S. ; Coleman, Rosalind A. ; Kraemer, Fredric B. ; McManaman, James L. ; Obin, Martin S. ; Puri, Vishwajeet ; Yan, Qing Wu ; Miyoshi, Hideaki ; Mashek, Douglas G. / The role of lipid droplets in metabolic disease in rodents and humans. In: Journal of Clinical Investigation. 2011 ; Vol. 121, No. 6. pp. 2102-2110.
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