The role of lipid droplets in metabolic disease in rodents and humans

Andrew S. Greenberg; Rosalind A. Coleman; Fredric B. Kraemer; James L. McManaman; Martin S. Obin; Vishwajeet Puri; Qing Wu Yan; Hideaki Miyoshi; Douglas G. Mashek

doi:10.1172/JCI46069

The role of lipid droplets in metabolic disease in rodents and humans

Andrew S. Greenberg, Rosalind A. Coleman, Fredric B. Kraemer, James L. McManaman, Martin S. Obin, Vishwajeet Puri, Qing Wu Yan, Hideaki Miyoshi, Douglas G. Mashek

Metabolic and Systems Biology (TMED)

Research output: Contribution to journal › Review article › peer-review

463 Scopus citations

Abstract

Lipid droplets (LDs) are intracellular organelles that store neutral lipids within cells. Over the last two decades there has been a dramatic growth in our understanding of LD biology and, in parallel, our understanding of the role of LDs in health and disease. In its simplest form, the LD regulates the storage and hydrolysis of neutral lipids, including triacylglycerol and/or cholesterol esters. It is becoming increasingly evident that alterations in the regulation of LD physiology and metabolism influence the risk of developing metabolic diseases such as diabetes. In this review we provide an update on the role of LD-associated proteins and LDs in metabolic disease.

Original language	English (US)
Pages (from-to)	2102-2110
Number of pages	9
Journal	Journal of Clinical Investigation
Volume	121
Issue number	6
DOIs	https://doi.org/10.1172/JCI46069
State	Published - Jun 1 2011

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Publisher link

10.1172/JCI46069

Find It

Find It at U of M Libraries

Cite this

@article{6e171ce1ba524349a859de4368c485af,

title = "The role of lipid droplets in metabolic disease in rodents and humans",

abstract = "Lipid droplets (LDs) are intracellular organelles that store neutral lipids within cells. Over the last two decades there has been a dramatic growth in our understanding of LD biology and, in parallel, our understanding of the role of LDs in health and disease. In its simplest form, the LD regulates the storage and hydrolysis of neutral lipids, including triacylglycerol and/or cholesterol esters. It is becoming increasingly evident that alterations in the regulation of LD physiology and metabolism influence the risk of developing metabolic diseases such as diabetes. In this review we provide an update on the role of LD-associated proteins and LDs in metabolic disease.",

author = "Greenberg, {Andrew S.} and Coleman, {Rosalind A.} and Kraemer, {Fredric B.} and McManaman, {James L.} and Obin, {Martin S.} and Vishwajeet Puri and Yan, {Qing Wu} and Hideaki Miyoshi and Mashek, {Douglas G.}",

year = "2011",

month = jun,

day = "1",

doi = "10.1172/JCI46069",

language = "English (US)",

volume = "121",

pages = "2102--2110",

journal = "Journal of Clinical Investigation",

issn = "0021-9738",

publisher = "The American Society for Clinical Investigation",

number = "6",

}

TY - JOUR

T1 - The role of lipid droplets in metabolic disease in rodents and humans

AU - Greenberg, Andrew S.

AU - Coleman, Rosalind A.

AU - Kraemer, Fredric B.

AU - McManaman, James L.

AU - Obin, Martin S.

AU - Puri, Vishwajeet

AU - Yan, Qing Wu

AU - Miyoshi, Hideaki

AU - Mashek, Douglas G.

PY - 2011/6/1

Y1 - 2011/6/1

N2 - Lipid droplets (LDs) are intracellular organelles that store neutral lipids within cells. Over the last two decades there has been a dramatic growth in our understanding of LD biology and, in parallel, our understanding of the role of LDs in health and disease. In its simplest form, the LD regulates the storage and hydrolysis of neutral lipids, including triacylglycerol and/or cholesterol esters. It is becoming increasingly evident that alterations in the regulation of LD physiology and metabolism influence the risk of developing metabolic diseases such as diabetes. In this review we provide an update on the role of LD-associated proteins and LDs in metabolic disease.

AB - Lipid droplets (LDs) are intracellular organelles that store neutral lipids within cells. Over the last two decades there has been a dramatic growth in our understanding of LD biology and, in parallel, our understanding of the role of LDs in health and disease. In its simplest form, the LD regulates the storage and hydrolysis of neutral lipids, including triacylglycerol and/or cholesterol esters. It is becoming increasingly evident that alterations in the regulation of LD physiology and metabolism influence the risk of developing metabolic diseases such as diabetes. In this review we provide an update on the role of LD-associated proteins and LDs in metabolic disease.

UR - http://www.scopus.com/inward/record.url?scp=79957889560&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79957889560&partnerID=8YFLogxK

U2 - 10.1172/JCI46069

DO - 10.1172/JCI46069

M3 - Review article

C2 - 21633178

AN - SCOPUS:79957889560

SN - 0021-9738

VL - 121

SP - 2102

EP - 2110

JO - Journal of Clinical Investigation

JF - Journal of Clinical Investigation

IS - 6

ER -

The role of lipid droplets in metabolic disease in rodents and humans

Abstract

UN SDGs

Publisher link

Find It

Other files and links

Fingerprint

Cite this