The role of lipid abnormalities in the pathogenesis of chronic, progressive renal disease.

Bert L Kasiske, M. P. O'Donnell, P. G. Schmitz, W. F. Keane

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations

Abstract

Altogether, a growing amount of clinical and experimental data suggests that lipids may be important in the development and progression of chronic renal injury. Abundant clinical data have demonstrated that hyperlipidemia is associated with diabetes, decreased renal function, and the nephrotic syndrome. Although clinical correlations between plasma lipid levels and renal dysfunction do not prove a cause-and-effect relationship, potentially injurious lipid abnormalities are invariably present in those patients most likely to progress to end-stage renal disease. In several animal models, pharmacologic treatment of lipid abnormalities has been shown to ameliorate renal disease. Moreover, experimental data suggest that lipid-induced alterations in a number of immune and nonimmune mechanisms could explain the association between lipids and renal injury. A better understanding of these alterations and mechanisms may ultimately lead to more effective treatment of patients with chronic progressive renal disease.

Original languageEnglish (US)
Pages (from-to)109-125
Number of pages17
JournalAdvances in nephrology from the Necker Hospital
Volume20
StatePublished - 1991

Fingerprint

Dive into the research topics of 'The role of lipid abnormalities in the pathogenesis of chronic, progressive renal disease.'. Together they form a unique fingerprint.

Cite this