The role of LANP and ataxin 1 in E4F-mediated transcriptional repression

Marija Cvetanovic; Robert J. Rooney; Jesus J. Garcia; Nataliya Toporovskaya; Huda Y. Zoghbi; Puneet Opal

doi:10.1038/sj.embor.7400983

The role of LANP and ataxin 1 in E4F-mediated transcriptional repression

Marija Cvetanovic, Robert J. Rooney, Jesus J. Garcia, Nataliya Toporovskaya, Huda Y. Zoghbi, Puneet Opal

Neuroscience

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

The leucine-rich acidic nuclear protein (LANP) belongs to the INHAT family of corepressors that inhibits histone acetyltransferases. The mechanism by which LANP restricts its repression to specific genes is unknown. Here, we report that LANP forms a complex with transcriptional repressor E4F and modulates its activity. As LANP interacts with ataxin 1 - a protein mutated in the neurodegenerative disease spinocerebellar ataxia type 1 (SCA1) - we tested whether ataxin 1 can alter the E4F-LANP interaction. We show that ataxin 1 relieves the transcriptional repression induced by the LANP-E4F complex by competing with E4F for LANP. These results provide the first functional link, to our knowledge, between LANP and ataxin 1, and indicate a potential mechanism for the transcriptional aberrations observed in SCA1.

Original language	English (US)
Pages (from-to)	671-677
Number of pages	7
Journal	EMBO Reports
Volume	8
Issue number	7
DOIs	https://doi.org/10.1038/sj.embor.7400983
State	Published - Jul 2007

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Publisher link

10.1038/sj.embor.7400983

Find It

Find It at U of M Libraries

Cite this

@article{44d6328a1d0343c8ad00ea2efd9f6fb7,

title = "The role of LANP and ataxin 1 in E4F-mediated transcriptional repression",

abstract = "The leucine-rich acidic nuclear protein (LANP) belongs to the INHAT family of corepressors that inhibits histone acetyltransferases. The mechanism by which LANP restricts its repression to specific genes is unknown. Here, we report that LANP forms a complex with transcriptional repressor E4F and modulates its activity. As LANP interacts with ataxin 1 - a protein mutated in the neurodegenerative disease spinocerebellar ataxia type 1 (SCA1) - we tested whether ataxin 1 can alter the E4F-LANP interaction. We show that ataxin 1 relieves the transcriptional repression induced by the LANP-E4F complex by competing with E4F for LANP. These results provide the first functional link, to our knowledge, between LANP and ataxin 1, and indicate a potential mechanism for the transcriptional aberrations observed in SCA1.",

author = "Marija Cvetanovic and Rooney, {Robert J.} and Garcia, {Jesus J.} and Nataliya Toporovskaya and Zoghbi, {Huda Y.} and Puneet Opal",

year = "2007",

month = jul,

doi = "10.1038/sj.embor.7400983",

language = "English (US)",

volume = "8",

pages = "671--677",

journal = "EMBO Reports",

issn = "1469-221X",

publisher = "EMBO Press",

number = "7",

}

TY - JOUR

T1 - The role of LANP and ataxin 1 in E4F-mediated transcriptional repression

AU - Cvetanovic, Marija

AU - Rooney, Robert J.

AU - Garcia, Jesus J.

AU - Toporovskaya, Nataliya

AU - Zoghbi, Huda Y.

AU - Opal, Puneet

PY - 2007/7

Y1 - 2007/7

N2 - The leucine-rich acidic nuclear protein (LANP) belongs to the INHAT family of corepressors that inhibits histone acetyltransferases. The mechanism by which LANP restricts its repression to specific genes is unknown. Here, we report that LANP forms a complex with transcriptional repressor E4F and modulates its activity. As LANP interacts with ataxin 1 - a protein mutated in the neurodegenerative disease spinocerebellar ataxia type 1 (SCA1) - we tested whether ataxin 1 can alter the E4F-LANP interaction. We show that ataxin 1 relieves the transcriptional repression induced by the LANP-E4F complex by competing with E4F for LANP. These results provide the first functional link, to our knowledge, between LANP and ataxin 1, and indicate a potential mechanism for the transcriptional aberrations observed in SCA1.

AB - The leucine-rich acidic nuclear protein (LANP) belongs to the INHAT family of corepressors that inhibits histone acetyltransferases. The mechanism by which LANP restricts its repression to specific genes is unknown. Here, we report that LANP forms a complex with transcriptional repressor E4F and modulates its activity. As LANP interacts with ataxin 1 - a protein mutated in the neurodegenerative disease spinocerebellar ataxia type 1 (SCA1) - we tested whether ataxin 1 can alter the E4F-LANP interaction. We show that ataxin 1 relieves the transcriptional repression induced by the LANP-E4F complex by competing with E4F for LANP. These results provide the first functional link, to our knowledge, between LANP and ataxin 1, and indicate a potential mechanism for the transcriptional aberrations observed in SCA1.

UR - http://www.scopus.com/inward/record.url?scp=34447094369&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34447094369&partnerID=8YFLogxK

U2 - 10.1038/sj.embor.7400983

DO - 10.1038/sj.embor.7400983

M3 - Article

C2 - 17557114

AN - SCOPUS:34447094369

SN - 1469-221X

VL - 8

SP - 671

EP - 677

JO - EMBO Reports

JF - EMBO Reports

IS - 7

ER -

The role of LANP and ataxin 1 in E4F-mediated transcriptional repression

Abstract

UN SDGs

Publisher link

Find It

Other files and links

Fingerprint

Cite this