The role of intestinal microflora in the metabolic reduction of 1-nitropyrene to 1-aminopyrene in conventional and germfree rats and in humans

Karam El-Bayoumy, Chand Sharma, Yves M. Louis, Bandaru Reddy, Stephen S. Hecht

Research output: Contribution to journalArticle

56 Scopus citations

Abstract

1-Nitropyrene (100 mg/kg body wt.) was administered by gavage to conventional and germfree Fischer 344 rats. 1-Aminopyrene was detected in the feces of conventional rats (5-6% of the dose) but not in the feces of germfree rats. Conjugates of 1-aminopyrene were not detected in the feces of germfree rats and neither 1-aminopyrene nor its conjugates were found in the urine of either conventional or germfree rats. Since reduction of 1-nitropyrene to 1-aminopyrene is an activation process, the results indicate that intestinal microflora are important in the metabolic activation of 1-nitropyrene in vivo in the rat. Human intestinal microflora also reduced 1-nitropyrene to 1-aminopyrene.

Original languageEnglish (US)
Pages (from-to)311-316
Number of pages6
JournalCancer Letters
Volume19
Issue number3
DOIs
StatePublished - Jul 1983

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