The role of IL-10 in Mycobacterium avium subsp. paratuberculosis infection

Tariq Hussain, Syed Zahid Ali Shah, Deming Zhao, Srinand Sreevatsan, Xiangmei Zhou

Research output: Contribution to journalReview articlepeer-review

38 Scopus citations


Mycobacterium avium subsp. paratuberculosis (MAP) is an intracellular pathogen and is the causative agent of Johne's disease of domestic and wild ruminants. Johne's disease is characterized by chronic granulomatous enteritis leading to substantial economic losses to the livestock sector across the world. MAP persistently survives in phagocytic cells, most commonly in macrophages by disrupting its early antibacterial activity. MAP triggers several signaling pathways after attachment to pathogen recognition receptors (PRRs) of phagocytic cells. MAP adopts a survival strategy to escape the host defence mechanisms via the activation of mitogen-activated protein kinase (MAPK) pathway. The signaling mechanism initiated through toll like receptor 2 (TLR2) activates MAPK-p38 results in up-regulation of interleukin-10 (IL-10), and subsequent repression of inflammatory cytokines. The anti-inflammatory response of IL-10 is mediated through membrane-bound IL-10 receptors, leading to trans-phosphorylation and activation of Janus Kinase (JAK) family receptor-associated tyrosine kinases (TyKs), that promotes the activation of latent transcription factors, signal transducer and activators of transcription 3 (STAT3). IL-10 is an important inhibitory cytokine playing its role in blocking phagosome maturation and apoptosis. In the current review, we describe the importance of IL-10 in early phases of the MAP infection and regulatory mechanisms of the IL-10 dependent pathways in paratuberculosis. We also highlight the strategies to target IL-10, MAPK and STAT3 in other infections caused by intracellular pathogens.

Original languageEnglish (US)
Pages (from-to)1-14
Number of pages14
JournalCell Communication and Signaling
Issue number1
StatePublished - Dec 1 2016

Bibliographical note

Publisher Copyright:
© 2016 The Author(s).


  • Interleukin-10 (IL-10)
  • Janus Kinase (JAK)
  • Mitogen-activated protein kinase (MAPK)
  • Mycobacterium avium subsp. paratuberculosis (MAP)
  • Signal transducer and activators of transcription-3 (STAT3)
  • Toll like receptor 2 (TLR2)


Dive into the research topics of 'The role of IL-10 in Mycobacterium avium subsp. paratuberculosis infection'. Together they form a unique fingerprint.

Cite this