The Role of Hexon Protein as a Molecular Mold in Patterning the Protein IX Organization in Human Adenoviruses

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Abstract

Adenoviruses are respiratory, ocular and enteric pathogens that form complex capsids, which are assembled from seven different structural proteins and composed of several core proteins that closely interact with the packaged dsDNA genome. The recent near-atomic resolution structures revealed that the interlacing continuous hexagonal network formed by the protein IX molecules is conserved among different human adenoviruses (HAdVs), but not in non-HAdVs. In this report, we propose a distinct role for the hexon protein as a “molecular mold” in enabling the formation of such hexagonal protein IX network that has been shown to preserve the stability and infectivity of HAdVs.

Original languageEnglish (US)
Pages (from-to)2747-2751
Number of pages5
JournalJournal of Molecular Biology
Volume429
Issue number18
DOIs
StatePublished - Sep 1 2017
Externally publishedYes

Bibliographical note

Funding Information:
This work was supported by the National Institutes of Health (Grants R01AI070771 and R21AI103692).

Publisher Copyright:
© 2017 Elsevier Ltd

Keywords

  • adenovirus structure
  • hexon
  • molecular mold
  • protein IX
  • protein network

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