The role of FSH in body composition in hematopoietic cell transplant recipients

Erica J. Roelofs, Donald R. Dengel, Qi Wang, James S. Hodges, Julia Steinberger, Scott Baker

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BACKGROUND: Childhood cancer survivors who received a hematopoietic cell transplantation (HCT) are at increased risk for follicle-stimulating hormone (FSH) abnormalities, which may have a significant negative impact on bone health and body composition. This study's purpose was to examine FSH and body composition in HCT recipients, non-HCT recipients and healthy controls.

METHODS: The study included HCT recipients (n = 24), non-HCT recipients (n = 309), and a control group of healthy siblings (n = 211) all aged 9-18 years. A fasting blood sample was collected to measure FSH. All participants underwent a dual X-ray absorptiometry scan to assess total and regional percent fat, lean mass (LM), fat mass (FM), bone mineral content (BMC), bone mineral density (BMD), and visceral adipose tissue (VAT) mass.

RESULTS: FSH was significantly higher in HCT recipients compared to non-HCT recipients and healthy controls. HCT recipients had significantly lower total body weight, total LM, arm and leg LM, BMC and BMD compared to non-HCT recipients and healthy controls (p < .05). Non-HCT recipients had significantly higher total, trunk, android, gynoid, arm and leg FM compared to healthy controls. Also, healthy controls had significantly lower VAT mass compared to non-HCT recipients.

CONCLUSIONS: This study's results show that HCT recipients have significant reductions in BMD, worse body composition, and abnormal FSH levels compared to non-HCT recipients and healthy controls.

Original languageEnglish (US)
Article numbere14130
JournalPediatric transplantation
Issue number1
Early online dateSep 5 2021
StatePublished - Feb 2022

Bibliographical note

Funding Information:
Supported by the National Institutes of Health (grants R01 CA113930 [to J.S.] and R01CA112530 [to K.S.B.]), the General Clinical Research Center Program (grant M01‐RR00400), National Center for Research Resources (grant 1UL1‐RR033183), and the Clinical and Translational Science Institute at the University of Minnesota‐Twin Cities (grant UL1TR000114). Statistical support was provided by the National Center for Advancing Translational Sciences of the National Institutes of Health Award Number UL1TR000114.

Publisher Copyright:
© 2021 Wiley Periodicals LLC.

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