The role of blood rheology in sickle cell disease

Philippe Connes, Tamas Alexy, Jon Detterich, Marc Romana, Marie Dominique Hardy-Dessources, Samir K. Ballas

Research output: Contribution to journalArticlepeer-review

100 Scopus citations


Studies performed in the last decades have highlighted the need to better understand the contribution of the endothelium, vascular function, oxidative stress, inflammation, coagulation, hemolysis and vascular adhesion mechanisms to the pathophysiology of acute vaso-occlusive like events and chronic organ damages in sickle cell disease (SCD). Although SCD is a hemorheological disease, a few works focused on the contribution of blood viscosity, plasma viscosity, red blood cell deformability and aggregation in the pathophysiology of SCD. After a brief description of basic hemorheology, the present review focuses on the role of the hemorheological abnormalities in the causation of several SCD complications, mainly in sickle cell anemia and hemoglobin (Hb) SC disease. Several genetic and cellularmodulators of blood rheology in SCD are discussed, as well as unresolved questions and perspectives.

Original languageEnglish (US)
Pages (from-to)111-118
Number of pages8
JournalBlood Reviews
Issue number2
StatePublished - Mar 1 2016

Bibliographical note

Publisher Copyright:
© 2015 Elsevier Ltd.


  • Blood viscosity
  • Red blood cell aggregation
  • Red blood cell deformability
  • Sickle cell disease
  • Vaso-occlusive crises


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