The role of autophagy in tick-endosymbiont interactions: insights from Ixodes scapularis and Rickettsia buchneri

Xinru Wang, Benjamin Cull, Jonathan Oliver, Timothy J Kurtti, Ulrike G. Munderloh

Research output: Contribution to journalArticlepeer-review

Abstract

IMPORTANCE: Ticks are second only to mosquitoes in their importance as vectors of disease agents; however, tick-borne diseases (TBDs) account for the majority of all vector-borne disease cases in the United States (approximately 76.5%), according to Centers for Disease Control and Prevention reports. Newly discovered tick species and their associated disease-causing pathogens, and anthropogenic and demographic factors also contribute to the emergence and re-emergence of TBDs. Thus, incorporating different tick control approaches based on a thorough knowledge of tick biology has great potential to prevent and eliminate TBDs in the future. Here we demonstrate that replication of a transovarially transmitted rickettsial endosymbiont depends on the tick's autophagy machinery but not on apoptosis. Our findings improve our understanding of the role of symbionts in tick biology and the potential to discover tick control approaches to prevent or manage TBDs.

Original languageEnglish (US)
Pages (from-to)e0108623
JournalMicrobiology Spectrum
Volume12
Issue number1
DOIs
StatePublished - Jan 11 2024

Keywords

  • apoptosis
  • autophagy
  • Rickettsia buchneri
  • tick-endosymbiont interactions

PubMed: MeSH publication types

  • Journal Article

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