The road to physiological maturation of stem cell-derived cardiac muscle runs through the sarcomere

Research output: Contribution to journalShort surveypeer-review

Abstract

Recent advances the cardiac biomedical sciences have been propelled forward by the development and implementation of human iPSC-derived cardiac muscle. These notable successes notwithstanding, it is well recognized in the field that a major roadblock persists in the lack of full “adult cardiac muscle-like” maturation of hiPSC-CMs. This Perspective centers focus on maturation roadblocks in the essential physiological unit of muscle, the sarcomere. Stalled sarcomere maturation must be addressed and overcome before this elegant experimental platform can reach the mountaintop of making impactful contributions in disease pathogenesis, drug discovery, and in clinical regenerative medicine.

Original languageEnglish (US)
Pages (from-to)117-120
Number of pages4
JournalJournal of Molecular and Cellular Cardiology
Volume170
DOIs
StatePublished - Sep 2022

Bibliographical note

Funding Information:
I am most grateful to the current and past Metzger lab members for their many contributions to advancing discoveries in the biomedical sciences.

Publisher Copyright:
© 2022

Keywords

  • Maturation
  • Sarcomere
  • hiPSC-CM

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

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