Recent advances the cardiac biomedical sciences have been propelled forward by the development and implementation of human iPSC-derived cardiac muscle. These notable successes notwithstanding, it is well recognized in the field that a major roadblock persists in the lack of full “adult cardiac muscle-like” maturation of hiPSC-CMs. This Perspective centers focus on maturation roadblocks in the essential physiological unit of muscle, the sarcomere. Stalled sarcomere maturation must be addressed and overcome before this elegant experimental platform can reach the mountaintop of making impactful contributions in disease pathogenesis, drug discovery, and in clinical regenerative medicine.
|Original language||English (US)|
|Number of pages||4|
|Journal||Journal of Molecular and Cellular Cardiology|
|State||Published - Sep 2022|
Bibliographical noteFunding Information:
I am most grateful to the current and past Metzger lab members for their many contributions to advancing discoveries in the biomedical sciences.
PubMed: MeSH publication types
- Journal Article
- Research Support, N.I.H., Extramural
- Research Support, Non-U.S. Gov't