The risk of second primary tumors in head and neck cancer: A systematic review

Andrés Coca-Pelaz; Juan P. Rodrigo; Carlos Suárez; Iain J. Nixon; Antti Mäkitie; Alvaro Sanabria; Miquel Quer; Primož Strojan; Carol R. Bradford; Luiz P. Kowalski; Ashok R. Shaha; Remco de Bree; Dana M. Hartl; Alessandra Rinaldo; Robert P. Takes; Alfio Ferlito

doi:10.1002/hed.26016

The risk of second primary tumors in head and neck cancer: A systematic review

Andrés Coca-Pelaz
, Juan P. Rodrigo
, Carlos Suárez
, Iain J. Nixon
, Antti Mäkitie
, Alvaro Sanabria
, Miquel Quer
, Primož Strojan
, Carol R. Bradford
, Luiz P. Kowalski
, Ashok R. Shaha
, Remco de Bree
, Dana M. Hartl
, Alessandra Rinaldo
, Robert P. Takes
, Alfio Ferlito

Research output: Contribution to journal › Article › peer-review

84 Scopus citations

Abstract

Background: Second primary tumors (SPTs) are a common cause of reduced life expectancy in patients treated for head and neck cancer (HNC). This phenomenon forms an area to be addressed during posttreatment follow-up. Methods: We conducted a systematic review of literature following PRISMA guidelines, from 1979 to 2019, to investigate incidence of SPTs, synchronous, and metachronous, in HNC population. Results: Our review includes data of 456 130 patients from 61 articles. With a minimum follow-up of 22 months, mean incidence of SPTs was 13.2% (95% CI: 11.56-14.84): 5.3% (95% CI: 4.24-6.36) for synchronous SPTs and 9.4% (95% CI: 7.9-10.9) for metachronous SPTs. The most frequent site for SPTs was head and neck area, followed by the lungs and esophagus. Conclusion: Although with wide variations between studies, the rate of SPTs in HNC patients is high. Given the impact in the prognosis, we must develop strategies for the early diagnosis of SPTs.

Original language	English (US)
Pages (from-to)	456-466
Number of pages	11
Journal	Head and Neck
Volume	42
Issue number	3
DOIs	https://doi.org/10.1002/hed.26016
State	Published - Mar 1 2020
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2019 Wiley Periodicals, Inc.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

head and neck cancer
metachronous
second primary tumor
squamous cell carcinoma
synchronous

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10.1002/hed.26016

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Coca-Pelaz, A., Rodrigo, J. P., Suárez, C., Nixon, I. J., Mäkitie, A., Sanabria, A., Quer, M., Strojan, P., Bradford, C. R., Kowalski, L. P., Shaha, A. R., de Bree, R., Hartl, D. M., Rinaldo, A., Takes, R. P., & Ferlito, A. (2020). The risk of second primary tumors in head and neck cancer: A systematic review. Head and Neck, 42(3), 456-466. https://doi.org/10.1002/hed.26016

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abstract = "Background: Second primary tumors (SPTs) are a common cause of reduced life expectancy in patients treated for head and neck cancer (HNC). This phenomenon forms an area to be addressed during posttreatment follow-up. Methods: We conducted a systematic review of literature following PRISMA guidelines, from 1979 to 2019, to investigate incidence of SPTs, synchronous, and metachronous, in HNC population. Results: Our review includes data of 456 130 patients from 61 articles. With a minimum follow-up of 22 months, mean incidence of SPTs was 13.2\% (95\% CI: 11.56-14.84): 5.3\% (95\% CI: 4.24-6.36) for synchronous SPTs and 9.4\% (95\% CI: 7.9-10.9) for metachronous SPTs. The most frequent site for SPTs was head and neck area, followed by the lungs and esophagus. Conclusion: Although with wide variations between studies, the rate of SPTs in HNC patients is high. Given the impact in the prognosis, we must develop strategies for the early diagnosis of SPTs.",

keywords = "head and neck cancer, metachronous, second primary tumor, squamous cell carcinoma, synchronous",

author = "Andr{\'e}s Coca-Pelaz and Rodrigo, \{Juan P.\} and Carlos Su{\'a}rez and Nixon, \{Iain J.\} and Antti M{\"a}kitie and Alvaro Sanabria and Miquel Quer and Primo{\v z} Strojan and Bradford, \{Carol R.\} and Kowalski, \{Luiz P.\} and Shaha, \{Ashok R.\} and \{de Bree\}, Remco and Hartl, \{Dana M.\} and Alessandra Rinaldo and Takes, \{Robert P.\} and Alfio Ferlito",

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doi = "10.1002/hed.26016",

language = "English (US)",

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AU - Coca-Pelaz, Andrés

AU - Rodrigo, Juan P.

AU - Suárez, Carlos

AU - Nixon, Iain J.

AU - Mäkitie, Antti

AU - Sanabria, Alvaro

AU - Quer, Miquel

AU - Strojan, Primož

AU - Bradford, Carol R.

AU - Kowalski, Luiz P.

AU - Shaha, Ashok R.

AU - de Bree, Remco

AU - Hartl, Dana M.

AU - Rinaldo, Alessandra

AU - Takes, Robert P.

AU - Ferlito, Alfio

PY - 2020/3/1

Y1 - 2020/3/1

N2 - Background: Second primary tumors (SPTs) are a common cause of reduced life expectancy in patients treated for head and neck cancer (HNC). This phenomenon forms an area to be addressed during posttreatment follow-up. Methods: We conducted a systematic review of literature following PRISMA guidelines, from 1979 to 2019, to investigate incidence of SPTs, synchronous, and metachronous, in HNC population. Results: Our review includes data of 456 130 patients from 61 articles. With a minimum follow-up of 22 months, mean incidence of SPTs was 13.2% (95% CI: 11.56-14.84): 5.3% (95% CI: 4.24-6.36) for synchronous SPTs and 9.4% (95% CI: 7.9-10.9) for metachronous SPTs. The most frequent site for SPTs was head and neck area, followed by the lungs and esophagus. Conclusion: Although with wide variations between studies, the rate of SPTs in HNC patients is high. Given the impact in the prognosis, we must develop strategies for the early diagnosis of SPTs.

AB - Background: Second primary tumors (SPTs) are a common cause of reduced life expectancy in patients treated for head and neck cancer (HNC). This phenomenon forms an area to be addressed during posttreatment follow-up. Methods: We conducted a systematic review of literature following PRISMA guidelines, from 1979 to 2019, to investigate incidence of SPTs, synchronous, and metachronous, in HNC population. Results: Our review includes data of 456 130 patients from 61 articles. With a minimum follow-up of 22 months, mean incidence of SPTs was 13.2% (95% CI: 11.56-14.84): 5.3% (95% CI: 4.24-6.36) for synchronous SPTs and 9.4% (95% CI: 7.9-10.9) for metachronous SPTs. The most frequent site for SPTs was head and neck area, followed by the lungs and esophagus. Conclusion: Although with wide variations between studies, the rate of SPTs in HNC patients is high. Given the impact in the prognosis, we must develop strategies for the early diagnosis of SPTs.

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KW - metachronous

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The risk of second primary tumors in head and neck cancer: A systematic review

Abstract

Bibliographical note

UN SDGs

Keywords

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