The rev Gene of Visna Virus Is Required for Productive Infection

Kathy L. Toohey, Ashley T. Haase

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

To assess the role of the animal lentivirus rev regulatory gene product in the life cycle of visna virus, we introduced mutations into the functional fourth exon of the rev gene of visna virus. Cultured cells transfected with a full-length clone of visna DNA produce infectious virus but visna DNA with mutations in rev does not. The documented requirement for a functional rev gene in productive infections establishes the essential role of this gene in the replication of an animal lentivirus.

Original languageEnglish (US)
Article number71186
Pages (from-to)276-280
Number of pages5
JournalVirology
Volume200
Issue number1
DOIs
StatePublished - Apr 1994

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