The retrovirus capsid core

Wei Zhang, Luiza Mendonça, Louis L. Mansky

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The retrovirus capsid core is a metastable structure that disassembles during the early phase of viral infection after membrane fusion. The core is intact and permeable to essential nucleotides during reverse transcription, but it undergoes disassembly for nuclear entry and genome integration. Increasing or decreasing the stability of the capsid core has a substantial negative impact on virus infectivity, which makes the core an attractive anti-viral target. The retrovirus capsid core also encounters a variety of virus- and organism-specific host cellular factors that promote or restrict viral replication. This review describes the structural elements fundamental to the formation and stability of the capsid core. The physical and chemical properties of the capsid core that are critical to its functional role in reverse transcription and interaction with host cellular factors are highlighted to emphasize areas of current research.

Original languageEnglish (US)
Title of host publicationSubcellular Biochemistry
PublisherSpringer New York
Pages169-187
Number of pages19
DOIs
StatePublished - Jan 1 2018

Publication series

NameSubcellular Biochemistry
Volume88
ISSN (Print)0306-0225

Keywords

  • Capsid
  • Capsomer
  • Comparative
  • Maturation
  • Restriction factor
  • Retrovirus
  • Virus-host interaction

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  • Cite this

    Zhang, W., Mendonça, L., & Mansky, L. L. (2018). The retrovirus capsid core. In Subcellular Biochemistry (pp. 169-187). (Subcellular Biochemistry; Vol. 88). Springer New York. https://doi.org/10.1007/978-981-10-8456-0_8