The Response of Cancer Cell Populations to Therapies

Danika Lindsay, Colleen M. Garvey, Shannon M. Mumenthaler, Jasmine Y Foo

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


In this chapter we discuss, from an evolutionary perspective, the response of cancer cell populations to therapeutic intervention. There are many factors that influence therapeutic response. Here we focus on examples of cell-intrinsic and -extrinsic mechanisms of current interest to the cancer biology and evolution communities: the roles of (1) phenotypic plasticity and (2) the tumor microenvironment.

Original languageEnglish (US)
Title of host publicationEcology and Evolution of Cancer
PublisherElsevier Inc.
Number of pages16
ISBN (Electronic)9780128043806
ISBN (Print)9780128043103
StatePublished - Feb 14 2017


  • Cancer treatment response
  • Plasticity
  • Tumor microenvironment


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