The relative expression amounts of apterous and its co-factor dLdb/Chip are critical for dorso-ventral compartmentalization in the Drosophila wing

Pedro Fernández-Fúnez, Cheng Hsin Lu, Diego E. Rincón-Limas, Antonio García-Bellido, Juan Botas

Research output: Contribution to journalArticlepeer-review

83 Scopus citations

Abstract

Dorso-ventral axis formation in the Drosophila wing requires the localized accumulation of the Apterous LIM/homeodomain protein (Ap) in dorsal cells. Here we report that dLdb/Chip encodes a LIM-binding co-factor that controls Ap activity. Both lack and excess of dLdb/Chip function cause the same phenotype as apterous (ap) lack of function; i.e. dorsal to ventral transformations, generation of new wing margins, and wing outgrowths. These results indicate that the normal function of Ap in dorso-ventral compartmentalization requires the correct amount of the DLDB/CHIP cofactor, and suggest that the Ap and DLDB/CHIP proteins form a multimeric functional complex. In support of this model, we show that the dLdb/Chip excess-of-function phenotypes can be rescued by ap overexpression.

Original languageEnglish (US)
Pages (from-to)6846-6853
Number of pages8
JournalEMBO Journal
Volume17
Issue number23
DOIs
StatePublished - Dec 1 1998

Keywords

  • Apterous
  • Co-factor
  • Compartment
  • LDB
  • LIM domain

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