The Relationships between Cold Ischemia Time, Kidney Transplant Length of Stay, and Transplant-related Costs

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Abstract

Background Recent changes in policies guiding allocation of transplant kidneys are predicted to increase sharing between distant geographic regions. The potential exists for an increase in cold ischemia time (CIT) with resulting increases in delayed graft function (DGF) and transplant-related costs (TRC). We sought to explore the impact of CIT on metrics that may influence TRC. Methods Between 2006 and 2014, 81 945 adult solitary deceased donor kidney transplants were performed in the United States; 477 (0.6%) at our institution. Regression models were constructed to describe the relationship between CIT on DGF and length of stay (LOS). Using hospital accounting data, we created regression models to evaluate the effect of DGF on LOS and TRC. Results In multivariable models, longer CIT was associated with an increased rate of DGF (odds ratio [OR], 1.41; 95% confidence interval [CI], 1.38-1.44) and increased LOS (OR, 1.04; 95% CI, 1.02-1.05). Recipients at our institution who developed DGF had longer LOS (OR, 1.71; 95% CI, 1.50-1.95), suggesting that the effect is partially mediated by DGF. After adjusting for LOS, neither CIT nor DGF were independently associated with increased TRC. However, an increased LOS resulted in an increase in TRC by US $3422 (95% CI, US $3180 to US $3664) per additional day, indicating that the effect of CIT on TRC is partially mediated through LOS. Conclusions The prolongation of CIT is associated with an increase in DGF rates and LOS, resulting in increased TRC. This study raises the need to balance increased access of traditionally underserved populations to kidney transplant with the inadvertent increase in TRC.

Original languageEnglish (US)
Pages (from-to)401-411
Number of pages11
JournalTransplantation
Volume103
Issue number2
DOIs
StatePublished - Feb 1 2019

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Cold Ischemia
Delayed Graft Function
Length of Stay
Transplants
Kidney
Costs and Cost Analysis
Confidence Intervals
Odds Ratio
Vulnerable Populations
Tissue Donors

PubMed: MeSH publication types

  • Journal Article

Cite this

@article{8d1155b23f9548c9ba5ea2a299a267b7,
title = "The Relationships between Cold Ischemia Time, Kidney Transplant Length of Stay, and Transplant-related Costs",
abstract = "Background Recent changes in policies guiding allocation of transplant kidneys are predicted to increase sharing between distant geographic regions. The potential exists for an increase in cold ischemia time (CIT) with resulting increases in delayed graft function (DGF) and transplant-related costs (TRC). We sought to explore the impact of CIT on metrics that may influence TRC. Methods Between 2006 and 2014, 81 945 adult solitary deceased donor kidney transplants were performed in the United States; 477 (0.6{\%}) at our institution. Regression models were constructed to describe the relationship between CIT on DGF and length of stay (LOS). Using hospital accounting data, we created regression models to evaluate the effect of DGF on LOS and TRC. Results In multivariable models, longer CIT was associated with an increased rate of DGF (odds ratio [OR], 1.41; 95{\%} confidence interval [CI], 1.38-1.44) and increased LOS (OR, 1.04; 95{\%} CI, 1.02-1.05). Recipients at our institution who developed DGF had longer LOS (OR, 1.71; 95{\%} CI, 1.50-1.95), suggesting that the effect is partially mediated by DGF. After adjusting for LOS, neither CIT nor DGF were independently associated with increased TRC. However, an increased LOS resulted in an increase in TRC by US $3422 (95{\%} CI, US $3180 to US $3664) per additional day, indicating that the effect of CIT on TRC is partially mediated through LOS. Conclusions The prolongation of CIT is associated with an increase in DGF rates and LOS, resulting in increased TRC. This study raises the need to balance increased access of traditionally underserved populations to kidney transplant with the inadvertent increase in TRC.",
author = "Oscar Serrano and Vock, {David M} and Srinath Chinnakotla and Dunn, {Ty B} and Raja Kandaswamy and Pruett, {Timothy L} and Feldman, {Roger D} and Matas, {Arthur J} and Finger, {Erik B}",
year = "2019",
month = "2",
day = "1",
doi = "10.1097/TP.0000000000002309",
language = "English (US)",
volume = "103",
pages = "401--411",
journal = "Transplantation",
issn = "0041-1337",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - The Relationships between Cold Ischemia Time, Kidney Transplant Length of Stay, and Transplant-related Costs

AU - Serrano, Oscar

AU - Vock, David M

AU - Chinnakotla, Srinath

AU - Dunn, Ty B

AU - Kandaswamy, Raja

AU - Pruett, Timothy L

AU - Feldman, Roger D

AU - Matas, Arthur J

AU - Finger, Erik B

PY - 2019/2/1

Y1 - 2019/2/1

N2 - Background Recent changes in policies guiding allocation of transplant kidneys are predicted to increase sharing between distant geographic regions. The potential exists for an increase in cold ischemia time (CIT) with resulting increases in delayed graft function (DGF) and transplant-related costs (TRC). We sought to explore the impact of CIT on metrics that may influence TRC. Methods Between 2006 and 2014, 81 945 adult solitary deceased donor kidney transplants were performed in the United States; 477 (0.6%) at our institution. Regression models were constructed to describe the relationship between CIT on DGF and length of stay (LOS). Using hospital accounting data, we created regression models to evaluate the effect of DGF on LOS and TRC. Results In multivariable models, longer CIT was associated with an increased rate of DGF (odds ratio [OR], 1.41; 95% confidence interval [CI], 1.38-1.44) and increased LOS (OR, 1.04; 95% CI, 1.02-1.05). Recipients at our institution who developed DGF had longer LOS (OR, 1.71; 95% CI, 1.50-1.95), suggesting that the effect is partially mediated by DGF. After adjusting for LOS, neither CIT nor DGF were independently associated with increased TRC. However, an increased LOS resulted in an increase in TRC by US $3422 (95% CI, US $3180 to US $3664) per additional day, indicating that the effect of CIT on TRC is partially mediated through LOS. Conclusions The prolongation of CIT is associated with an increase in DGF rates and LOS, resulting in increased TRC. This study raises the need to balance increased access of traditionally underserved populations to kidney transplant with the inadvertent increase in TRC.

AB - Background Recent changes in policies guiding allocation of transplant kidneys are predicted to increase sharing between distant geographic regions. The potential exists for an increase in cold ischemia time (CIT) with resulting increases in delayed graft function (DGF) and transplant-related costs (TRC). We sought to explore the impact of CIT on metrics that may influence TRC. Methods Between 2006 and 2014, 81 945 adult solitary deceased donor kidney transplants were performed in the United States; 477 (0.6%) at our institution. Regression models were constructed to describe the relationship between CIT on DGF and length of stay (LOS). Using hospital accounting data, we created regression models to evaluate the effect of DGF on LOS and TRC. Results In multivariable models, longer CIT was associated with an increased rate of DGF (odds ratio [OR], 1.41; 95% confidence interval [CI], 1.38-1.44) and increased LOS (OR, 1.04; 95% CI, 1.02-1.05). Recipients at our institution who developed DGF had longer LOS (OR, 1.71; 95% CI, 1.50-1.95), suggesting that the effect is partially mediated by DGF. After adjusting for LOS, neither CIT nor DGF were independently associated with increased TRC. However, an increased LOS resulted in an increase in TRC by US $3422 (95% CI, US $3180 to US $3664) per additional day, indicating that the effect of CIT on TRC is partially mediated through LOS. Conclusions The prolongation of CIT is associated with an increase in DGF rates and LOS, resulting in increased TRC. This study raises the need to balance increased access of traditionally underserved populations to kidney transplant with the inadvertent increase in TRC.

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U2 - 10.1097/TP.0000000000002309

DO - 10.1097/TP.0000000000002309

M3 - Article

VL - 103

SP - 401

EP - 411

JO - Transplantation

JF - Transplantation

SN - 0041-1337

IS - 2

ER -