The relationship between oxidized LDL and other cardiovascular risk factors and subclinical CVD in different ethnic groups: The Multi-Ethnic Study of Atherosclerosis (MESA)

Paul Holvoet, Nancy S. Jenny, Pamela J. Schreiner, Russell P. Tracy, David R. Jacobs

Research output: Contribution to journalArticlepeer-review

117 Scopus citations

Abstract

Several groups have demonstrated an association between established CHD and elevated oxidized LDL (oxLDL). The relation with cardiovascular risk factors and subclinical CVD is less clear. Therefore, we examined this association in the Multi-Ethnic Study of Atherosclerosis cohort: 879 persons without CHD, all non-statin users, examined cross-sectionally. oxLDL was measured with a monoclonal antibody 4E6-based ELISA. The presence of subclinical CVD was defined as plaque occurrence in carotid arteries with ≥25 stenosis, ankle-brachial blood pressure index (ABI) <0.9 and coronary calcification based on Agatston calcium score ≥ 200. In a multivariate model, dyslipidemia (adverse levels of cholesterol, HDL-cholesterol, triglycerides), inflammation (elevated fibrinogen), gender (male), ethnicity (Black), and current smoking explained the most variation in oxLDL (model R2 = 0.41). In bivariate analyses, persons with subclinical CVD had higher levels of oxLDL (1.22 mg/dl versus 0.95 mg/dl; P = 0.0002). Adjustment for risk factor correlates attenuated associations with subclinical CVD (P = 0.026). In conclusion, oxLDL is associated with subclinical CVD by its relationship with many cardiovascular risk factors.

Original languageEnglish (US)
Pages (from-to)245-252
Number of pages8
JournalAtherosclerosis
Volume194
Issue number1
DOIs
StatePublished - Sep 2007

Bibliographical note

Funding Information:
This research was supported by contracts N01-HC-95159 through N01-HC-95165 and N01-HC-95169 from the National Heart, Lung, and Blood Institute: Coordinating Center (N01-HC-95159), UCLA Field Center (N01-HC-95160), Columbia University Field Center (N01-HC-95161), Columbia GCRC (RR-0645), Johns Hopkins University Field Center (N01-HC-95162), University of Minnesota Field Center (N01-HC-95163), Northwestern University Field Center (N01-HC-95164), Wake Forest University Field Center (N01-HC-95165), Central Laboratory (N01-HC-95166), Ultrasound Reading Center (N01-HC-95167), MRI Reading Center (N01-HC-95168), CT Reading Center (N01-HC-95169). The authors thank the other investigators, the staff, and the participants of the MESA study for their valuable contributions. A full list of participating MESA investigators and institutions can be found at http://www.mesa-nhlbi.org . In Leuven, the Interuniversity Attraction Poles Program, Belgian Science Policy (P5/02) supported this work. We thank Mrs. M. Landeloos for excellent technical assistance.

Keywords

  • Atherosclerosis
  • Cardiovascular disease
  • Cardiovascular risk
  • Lipoproteins
  • Oxidized LDL

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