The relationship between CD4+ follicular helper T cells and CD8+ resident memory T cells: Sisters or distant cousins?

Changwei Peng, Stephen C. Jameson

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Independent studies over the last decade have characterized the properties of non-circulating CD8+ ‘resident’ memory T cells (TRM), which offer barrier protective immunity in non-lymphoid tissues and CD4+ follicular helper T cells (TFH), which mediate B-cell help in lymphoid sites. Despite their very different biological roles in the immune system, intriguing parallels have been noted between the trafficking properties and differentiation cues of these populations, parallels which have only sharpened with recent findings. In this review, we explore the features that underlie these similarities and discuss whether these indicate meaningful homologies in the development of CD8+ TRM and CD4+ TFH or reflect resemblances which are only ‘skin-deep’.

Original languageEnglish (US)
Pages (from-to)583-587
Number of pages5
JournalInternational Immunology
Issue number9
StatePublished - Sep 1 2020

Bibliographical note

Publisher Copyright:
© The Japanese Society for Immunology. 2020. All rights reserved.

Copyright 2021 Elsevier B.V., All rights reserved.


  • ICOS
  • KLF2
  • P2RX7
  • S1PR1

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural

Fingerprint Dive into the research topics of 'The relationship between CD4<sup>+</sup> follicular helper T cells and CD8<sup>+</sup> resident memory T cells: Sisters or distant cousins?'. Together they form a unique fingerprint.

Cite this