The relationship between cardiac hemodynamics and exercise tolerance in cystic fibrosis

Erik H. Van Iterson, Courtney M. Wheatley, Sarah E. Baker, Wayne J. Morgan, Eric M. Snyder

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Background: Individuals with cystic fibrosis (CF) have reduced pulmonary function and exercise tolerance. Additionally, these individuals may develop abnormal cardiac function. The implications of abnormal cardiac function on exercise tolerance are unclear in CF. Objective: Study relationships between exercise cardiac hemodynamics and exercise tolerance in CF. Methods: 17 CF and 25 controls participated in cardiopulmonary exercise testing to measure exercise duration and peak workload (PW). Cardiac index (QI) was measured using acetylene rebreathe and oxygen uptake (VO2) breath-by-breath. Forced expiratory volume in 1-second (FEV1) was performed at rest. Results: Peak QI was 6.7 ± 0.5 vs. 9.1 ± 0.3 mL/min/m2, CF vs. controls, respectively (P < 0.05). Linear regressions between QI (R2 = 0.63 and 0.51) and exercise duration or PW were stronger than VO2 (R2 = 0.35 and 0.37) or FEV1 (R2 = 0.34 and 0.36) in CF, respectively (P < 0.05). Conclusion: These data are clinically relevant suggesting attenuated cardiac function in addition to low airway function relate to exercise tolerance in CF.

Original languageEnglish (US)
Pages (from-to)283-290
Number of pages8
JournalHeart and Lung: Journal of Acute and Critical Care
Volume45
Issue number3
DOIs
StatePublished - May 1 2016

Bibliographical note

Funding Information:
This research was supported by the National Institutes of Health ( HL108962-03 ). Thank you to the individuals who participated in this study.

Keywords

  • CFTR
  • Cardiac output
  • Cardiopulmonary exercise test
  • Exercise capacity
  • Functional limitation
  • Pulmonary function
  • Stroke volume

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