The regulatory role of pioneer factors during cardiovascular lineage specification – A mini review

Javier E Sierra Pagan, Daniel J. Garry

Research output: Contribution to journalReview articlepeer-review

Abstract

Cardiovascular disease (CVD) remains the number one cause of death worldwide. Ischemic heart disease contributes to heart failure and has considerable morbidity and mortality. Therefore, alternative therapeutic strategies are urgently needed. One class of epigenetic regulators known as pioneer factors has emerged as an important tool for the development of regenerative therapies for the treatment of CVD. Pioneer factors bind closed chromatin and remodel it to drive lineage specification. Here, we review pioneer factors within the cardiovascular lineage, particularly during development and reprogramming and highlight the implications this field of research has for the future development of cardiac specific regenerative therapies.

Original languageEnglish (US)
Article number972591
JournalFrontiers in Cardiovascular Medicine
Volume9
DOIs
StatePublished - Aug 23 2022

Bibliographical note

Funding Information:
We are grateful for the support of the Department of Defense (Grant # 3002-11765-00089113).

Publisher Copyright:
Copyright © 2022 Sierra-Pagan and Garry.

Keywords

  • cardiac regeneration
  • chromatin remodeling
  • epigenetics
  • ETS factors
  • ETV2/ER71
  • pioneer factors
  • reprogramming

PubMed: MeSH publication types

  • Journal Article
  • Review

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