The regulation of liver glycogen synthetase D phosphatase by ATP and glucose

Daniel P. Gilboe, frank q Nuttall

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Synthetase D phosphatase activity in a liver glycogen pellet preparation is inhibited by ATP (physiological concentration). The inhibition can be reversed by glucose concentrations within the usual physiological range. Phosphophosphorylase activity decreases concomitantly with increasing synthetase I activity during the phosphatase incubation but the decrease is modest even in the presence of glucose. The glucose reversal of ATP inhibition is not the result of ATPase or glucokinase activities, which would reduce the ATP concentration. ATP, glucose and glucose 6-phosphate concentrations remain stable during the phosphatase assay.

Original languageEnglish (US)
Pages (from-to)164-171
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume53
Issue number1
DOIs
StatePublished - Jul 2 1973

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