The Recovery of Hibernating Hearts Lies on a Spectrum: from Bears in Nature to Patients with Coronary Artery Disease

Robert W. Colbert, Christopher T. Holley, Laura L Hocum Stone, Melanie Crampton, Selcuk Adabag, Santiago Garcia, Paul A Iaizzo, Herbert B Ward, Rosemary F Kelly, Edward O McFalls

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Clinicians often use the term “hibernating myocardium” in reference to patients with ischemic heart disease and decreased function within viable myocardial regions. Because the term is a descriptor of nature’s process of torpor, we provide a comparison of the adaptations observed in both conditions. In nature, hearts from hibernating animals undergo a shift in substrate preference in favor of fatty acids, while preserving glucose uptake and glycogen. Expression of electron transport chain proteins in mitochondria is decreased while antioxidant proteins including uncoupling protein-2 are increased. Similarly, hibernating hearts from patients have a comparable metabolic signature, with increased glucose uptake and glycogen accumulation and decreased oxygen consumption. In contrast to nature however, patients with hibernating hearts are at increased risk for arrhythmias, and contractility does not fully recover following revascularization. Clearly, additional interventions need to be advanced in patients with coronary artery disease and hibernating myocardium to prevent refractory heart failure.

Original languageEnglish (US)
Pages (from-to)244-252
Number of pages9
JournalJournal of cardiovascular translational research
Volume8
Issue number4
DOIs
StatePublished - Jun 20 2015

Keywords

  • Antioxidant
  • Coronary artery disease
  • Glycogen
  • Heart failure
  • Hibernating myocardium
  • Metabolism
  • Mitochondria
  • Revascularization
  • Torpor
  • Uncoupling protein

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