The ratio of the absolute lymphocyte count to the absolute monocyte count is associated with prognosis in Hodgkin's lymphoma: Correlation with tumor-associated macrophages

Youngwha Koh, Hyo Jeong Kang, Chansik Park, Dok Hyun Yoon, Shin Kim, Cheolwon Suh, Heounjeong Go, Ji Eun Kim, Chul Woo Kim, Jooryung Huh

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85 Scopus citations

Abstract

Background. Although most patients with classical Hodgkin's lymphoma (cHL) have a long survival duration, the current risk stratification is imperfect. A recent study suggested a prognostic role for the peripheral blood absolute lymphocyte count/absolute monocyte count (ALC/AMC) ratio at diagnosis in cHL. It is intriguing to investigate the significance of the ALC/AMC ratio in relation to tumor-associated macrophages (TAMs), yet another prognostic factor for cHL. Methods. We examined the prognostic impact of the ALC, AMC, and ALC/AMC ratio in 312 cHL patients (median age, 37 years) using receiver operating characteristic curve analysis for optimal cutoff values, and compared these with TAM content. Results. The median follow-up was 65 months (range, 0.1-245 months). On univariate analysis, a low ALC/AMC ratio (<2.9) was correlated with a poorer overall survival (OS) outcome. A subgroup analysis of patients with limited- stage disease showed that the ALC/AMC ratio was significantly correlated with the OS time. Multivariate analysis showed the ALC/AMC ratio to be an independent prognostic factor for OS outcome. A Spearman correlation test ofTAMcontent showed a negative correlation with the ALC/AMC ratio and a positive correlation with the peripheral blood macrophage percentage. Conclusions. This study suggests that the ALC/AMC ratio may be a simple, inexpensive, and independent prognostic factor for OS outcome in patients with cHL and may have a role in the stratification of cHL patients in addition to the International Prognostic Score and TAM content.

Original languageEnglish (US)
Pages (from-to)871-880
Number of pages10
JournalOncologist
Volume17
Issue number6
DOIs
StatePublished - 2012

Keywords

  • Hodgkin's lymphoma
  • Lymphocyte/monocyte ratio
  • Lymphocytes
  • Monocytes
  • Prognosis

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