The ratio of a urinary tobacco-specific lung carcinogen metabolite to cotinine is significantly higher in passive than in active smokers

Rachel I. Vogel; Steven G. Carmella; Irina Stepanov; Dorothy K. Hatsukami; Stephen S. Hecht

doi:10.3109/1354750X.2011.598565

The ratio of a urinary tobacco-specific lung carcinogen metabolite to cotinine is significantly higher in passive than in active smokers

Rachel I. Vogel, Steven G. Carmella, Irina Stepanov, Dorothy K. Hatsukami, Stephen S. Hecht

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol plus its glucuronides (total NNAL), metabolites of the lung carcinogen NNK, and total cotinine, metabolites of nicotine, are biomarkers of active and passive cigarette smoking. We calculated the total NNAL:total cotinine (×10 ³) ratio in 408 passive (infants, children, and adults) and 1088 active smokers. The weighted averages were 0.73 (95% confidence interval 0.71, 0.76) for passive smokers and 0.07 (0.06, 0.08) for active smokers (p<0.0001). These results demonstrate that cotinine measurements may underestimate exposure of passive smokers to the lung carcinogen NNK in second-hand cigarette smoke. The total NNAL:total cotinine (×10 ³) ratio may provide an improved biomarker for evaluating the health effects of passive smoking.

Original language	English (US)
Pages (from-to)	491-497
Number of pages	7
Journal	Biomarkers
Volume	16
Issue number	6
DOIs	https://doi.org/10.3109/1354750X.2011.598565
State	Published - Sep 2011

Bibliographical note

Funding Information:
This study was supported by grants no CA-81301, DA-01333, and DA-014538 from the US National Institutes of Health. The authors report no declaration of interest.

Keywords

NNAL
cotinine
passive smoking

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10.3109/1354750X.2011.598565

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title = "The ratio of a urinary tobacco-specific lung carcinogen metabolite to cotinine is significantly higher in passive than in active smokers",

abstract = "4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol plus its glucuronides (total NNAL), metabolites of the lung carcinogen NNK, and total cotinine, metabolites of nicotine, are biomarkers of active and passive cigarette smoking. We calculated the total NNAL:total cotinine (×10 3) ratio in 408 passive (infants, children, and adults) and 1088 active smokers. The weighted averages were 0.73 (95% confidence interval 0.71, 0.76) for passive smokers and 0.07 (0.06, 0.08) for active smokers (p<0.0001). These results demonstrate that cotinine measurements may underestimate exposure of passive smokers to the lung carcinogen NNK in second-hand cigarette smoke. The total NNAL:total cotinine (×10 3) ratio may provide an improved biomarker for evaluating the health effects of passive smoking.",

keywords = "NNAL, cotinine, passive smoking",

author = "Vogel, {Rachel I.} and Carmella, {Steven G.} and Irina Stepanov and Hatsukami, {Dorothy K.} and Hecht, {Stephen S.}",

note = "Funding Information: This study was supported by grants no CA-81301, DA-01333, and DA-014538 from the US National Institutes of Health. The authors report no declaration of interest.",

year = "2011",

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doi = "10.3109/1354750X.2011.598565",

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AU - Vogel, Rachel I.

AU - Carmella, Steven G.

AU - Stepanov, Irina

AU - Hatsukami, Dorothy K.

AU - Hecht, Stephen S.

N1 - Funding Information: This study was supported by grants no CA-81301, DA-01333, and DA-014538 from the US National Institutes of Health. The authors report no declaration of interest.

PY - 2011/9

Y1 - 2011/9

N2 - 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol plus its glucuronides (total NNAL), metabolites of the lung carcinogen NNK, and total cotinine, metabolites of nicotine, are biomarkers of active and passive cigarette smoking. We calculated the total NNAL:total cotinine (×10 3) ratio in 408 passive (infants, children, and adults) and 1088 active smokers. The weighted averages were 0.73 (95% confidence interval 0.71, 0.76) for passive smokers and 0.07 (0.06, 0.08) for active smokers (p<0.0001). These results demonstrate that cotinine measurements may underestimate exposure of passive smokers to the lung carcinogen NNK in second-hand cigarette smoke. The total NNAL:total cotinine (×10 3) ratio may provide an improved biomarker for evaluating the health effects of passive smoking.

AB - 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol plus its glucuronides (total NNAL), metabolites of the lung carcinogen NNK, and total cotinine, metabolites of nicotine, are biomarkers of active and passive cigarette smoking. We calculated the total NNAL:total cotinine (×10 3) ratio in 408 passive (infants, children, and adults) and 1088 active smokers. The weighted averages were 0.73 (95% confidence interval 0.71, 0.76) for passive smokers and 0.07 (0.06, 0.08) for active smokers (p<0.0001). These results demonstrate that cotinine measurements may underestimate exposure of passive smokers to the lung carcinogen NNK in second-hand cigarette smoke. The total NNAL:total cotinine (×10 3) ratio may provide an improved biomarker for evaluating the health effects of passive smoking.

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The ratio of a urinary tobacco-specific lung carcinogen metabolite to cotinine is significantly higher in passive than in active smokers

Abstract

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