Abstract
Short-term memory is an intrinsic property of paced cardiac myocytes that reflects the influence of pacing history, and not just the immediately preceding diastolic interval (DI), on the action potential duration (APD). Although it is recognized that short-term memory affects the dynamics of cardiac myocytes in general, and the onset of irregular cardiac rhythm in particular, its has never been adequately quantified or measured directly in experiments or numerical simulations, mainly due to the absence of appropriate techniques. As a result, very little is known about the rate- and species dependent behavior of short-term memory. In this study, we introduce a new approach that allows one to estimate how much short-term memory, M S, is present in the cardiac myocyte at different pacing rates. The new quantification is based on the fact that pacing history affects not only the APD, but the entire dynamics of paced cardiac myocytes, in particular the restitution curve. Using the patch clamp technique and numerical simulations, we measured short-term memory restitution-the dependence of M S on the cycle length-in isolated rabbit and guinea pig ventricular myocytes. In both species, M S is rate- and species-dependent, displaying a biphasic behavior as a function of cycle length. Moreover, our results indicate that there is a significant difference in M S measured between both species at small cycle lengths. Numerical simulations suggest that the kinetics of the rapidly activating delayed rectifier potassium current I Kr is partially responsible for this difference.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 35-47 |
| Number of pages | 13 |
| Journal | Journal of Biological Physics |
| Volume | 33 |
| Issue number | 1 |
| DOIs | |
| State | Published - Feb 1 2007 |
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Keywords
- Action potential duration
- Cardiac myocytes
- Restitution
- Short-term memory
Cite this
The rate- and species-dependence of short-term memory in cardiac myocytes. / Tolkacheva, Elena G.
In: Journal of Biological Physics, Vol. 33, No. 1, 01.02.2007, p. 35-47.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The rate- and species-dependence of short-term memory in cardiac myocytes
AU - Tolkacheva, Elena G.
PY - 2007/2/1
Y1 - 2007/2/1
N2 - Short-term memory is an intrinsic property of paced cardiac myocytes that reflects the influence of pacing history, and not just the immediately preceding diastolic interval (DI), on the action potential duration (APD). Although it is recognized that short-term memory affects the dynamics of cardiac myocytes in general, and the onset of irregular cardiac rhythm in particular, its has never been adequately quantified or measured directly in experiments or numerical simulations, mainly due to the absence of appropriate techniques. As a result, very little is known about the rate- and species dependent behavior of short-term memory. In this study, we introduce a new approach that allows one to estimate how much short-term memory, M S, is present in the cardiac myocyte at different pacing rates. The new quantification is based on the fact that pacing history affects not only the APD, but the entire dynamics of paced cardiac myocytes, in particular the restitution curve. Using the patch clamp technique and numerical simulations, we measured short-term memory restitution-the dependence of M S on the cycle length-in isolated rabbit and guinea pig ventricular myocytes. In both species, M S is rate- and species-dependent, displaying a biphasic behavior as a function of cycle length. Moreover, our results indicate that there is a significant difference in M S measured between both species at small cycle lengths. Numerical simulations suggest that the kinetics of the rapidly activating delayed rectifier potassium current I Kr is partially responsible for this difference.
AB - Short-term memory is an intrinsic property of paced cardiac myocytes that reflects the influence of pacing history, and not just the immediately preceding diastolic interval (DI), on the action potential duration (APD). Although it is recognized that short-term memory affects the dynamics of cardiac myocytes in general, and the onset of irregular cardiac rhythm in particular, its has never been adequately quantified or measured directly in experiments or numerical simulations, mainly due to the absence of appropriate techniques. As a result, very little is known about the rate- and species dependent behavior of short-term memory. In this study, we introduce a new approach that allows one to estimate how much short-term memory, M S, is present in the cardiac myocyte at different pacing rates. The new quantification is based on the fact that pacing history affects not only the APD, but the entire dynamics of paced cardiac myocytes, in particular the restitution curve. Using the patch clamp technique and numerical simulations, we measured short-term memory restitution-the dependence of M S on the cycle length-in isolated rabbit and guinea pig ventricular myocytes. In both species, M S is rate- and species-dependent, displaying a biphasic behavior as a function of cycle length. Moreover, our results indicate that there is a significant difference in M S measured between both species at small cycle lengths. Numerical simulations suggest that the kinetics of the rapidly activating delayed rectifier potassium current I Kr is partially responsible for this difference.
KW - Action potential duration
KW - Cardiac myocytes
KW - Restitution
KW - Short-term memory
UR - http://www.scopus.com/inward/record.url?scp=34748895976&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34748895976&partnerID=8YFLogxK
U2 - 10.1007/s10867-007-9040-5
DO - 10.1007/s10867-007-9040-5
M3 - Article
C2 - 19669551
AN - SCOPUS:34748895976
VL - 33
SP - 35
EP - 47
JO - Journal of Biological Physics
JF - Journal of Biological Physics
SN - 0092-0606
IS - 1
ER -