The pubertal stress recalibration hypothesis: Potential neural and behavioral consequences

Carrie E. DePasquale; Max P. Herzberg; Megan R. Gunnar

doi:10.1111/cdep.12429

The pubertal stress recalibration hypothesis: Potential neural and behavioral consequences

Carrie E. DePasquale, Max P. Herzberg, Megan R. Gunnar

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20 Scopus citations

Abstract

Recent research has suggested that the pubertal period provides an opportunity for recalibrating the stress-responsive systems in youth whose responses to stress have been altered by early adversity. Such recalibration may have cascading effects that affect brain and behavioral development. In this article, we consider a large, cross-species literature to demonstrate the potential importance of pubertal stress recalibration for understanding the development of psychopathology following early deprivation by caregivers. We review the evidence for recalibration of the hypothalamic-pituitary-adrenal axis in humans, examine research on rodents that has established mechanisms through which stress hormones affect brain structure and function, and summarize the literature on human neuroimaging to assess how these mechanisms may translate into changes in human behavior. Finally, we suggest ideas for elucidating the consequences of pubertal stress recalibration that will improve our understanding of adaptive and maladaptive adolescent behavior following early adversity.

Original language	English (US)
Pages (from-to)	249-256
Number of pages	8
Journal	Child Development Perspectives
Volume	15
Issue number	4
DOIs	https://doi.org/10.1111/cdep.12429
State	Published - Dec 2021

Bibliographical note

Funding Information:
This work was supported by the National Institutes of Health, grants R01 HD095904 (MRG), T32 MH015755 (CED), T32 MH100019, and TL1 TR002493 (MPH); the content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health?s National Center for Advancing Translational Sciences. We have no conflicts of interest to disclose.

Funding Information:
This work was supported by the National Institutes of Health, grants R01 HD095904 (MRG), T32 MH015755 (CED), T32 MH100019, and TL1 TR002493 (MPH); the content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health’s National Center for Advancing Translational Sciences. We have no conflicts of interest to disclose.

Publisher Copyright:
© 2021 The Authors. Child Development Perspectives © 2021 Society for Research in Child Development.

Keywords

cortisol
early life stress
pubertal stress recalibration

PubMed: MeSH publication types

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10.1111/cdep.12429

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abstract = "Recent research has suggested that the pubertal period provides an opportunity for recalibrating the stress-responsive systems in youth whose responses to stress have been altered by early adversity. Such recalibration may have cascading effects that affect brain and behavioral development. In this article, we consider a large, cross-species literature to demonstrate the potential importance of pubertal stress recalibration for understanding the development of psychopathology following early deprivation by caregivers. We review the evidence for recalibration of the hypothalamic-pituitary-adrenal axis in humans, examine research on rodents that has established mechanisms through which stress hormones affect brain structure and function, and summarize the literature on human neuroimaging to assess how these mechanisms may translate into changes in human behavior. Finally, we suggest ideas for elucidating the consequences of pubertal stress recalibration that will improve our understanding of adaptive and maladaptive adolescent behavior following early adversity.",

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author = "DePasquale, {Carrie E.} and Herzberg, {Max P.} and Gunnar, {Megan R.}",

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The pubertal stress recalibration hypothesis: Potential neural and behavioral consequences

Abstract

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