Abstract
Visual perception is abnormal in psychotic disorders such as schizophrenia. In addition to hallucinations, laboratory tests show differences in fundamental visual processes including contrast sensitivity, center-surround interactions, and perceptual organization. A number of hypotheses have been proposed to explain visual dysfunction in psychotic disorders, including an imbalance between excitation and inhibition. However, the precise neural basis of abnormal visual perception in people with psychotic psychopathology (PwPP) remains unknown. Here, we describe the behavioral and 7 tesla MRI methods we used to interrogate visual neurophysiology in PwPP as part of the Psychosis Human Connectome Project (HCP). In addition to PwPP (n = 66) and healthy controls (n = 43), we also recruited first-degree biological relatives (n = 44) in order to examine the role of genetic liability for psychosis in visual perception. Our visual tasks were designed to assess fundamental visual processes in PwPP, whereas MR spectroscopy enabled us to examine neurochemistry, including excitatory and inhibitory markers. We show that it is feasible to collect high-quality data across multiple psychophysical, functional MRI, and MR spectroscopy experiments with a sizable number of participants at a single research site. These data, in addition to those from our previously described 3 tesla experiments, will be made publicly available in order to facilitate further investigations by other research groups. By combining visual neuroscience techniques and HCP brain imaging methods, our experiments offer new opportunities to investigate the neural basis of abnormal visual perception in PwPP.
Original language | English (US) |
---|---|
Article number | 120060 |
Journal | NeuroImage |
Volume | 272 |
DOIs | |
State | Published - May 15 2023 |
Bibliographical note
Funding Information:This work was supported by funding from the National Institutes of Health (U01 MH108150). Salary support for MPS was provided in part by K01 MH120278, and salary support for CAO was provided in part by R01 MH111447. Support for MR scanning at the University of Minnesota Center for Magnetic Resonance Research was provided by P41 EB015894 and P30 NS076408. This work used tools from the University of Minnesota Clinical and Translational Science Institute that were supported by UL1 TR002494.
Funding Information:
This work was supported by funding from the National Institutes of Health (U01 MH108150). Salary support for MPS was provided in part by K01 MH120278, and salary support for CAO was provided in part by R01 MH111447. Support for MR scanning at the University of Minnesota Center for Magnetic Resonance Research was provided by P41 EB015894 and P30 NS076408. This work used tools from the University of Minnesota Clinical and Translational Science Institute that were supported by UL1 TR002494.
Publisher Copyright:
© 2023 The Author(s)
Keywords
- 7 tesla
- Biological relatives
- Bipolar disorder
- MR spectroscopy
- Schizophrenia
- Task fMRI
PubMed: MeSH publication types
- Journal Article
- Research Support, N.I.H., Extramural